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Gene: NUDT1 (nudix hydrolase 1) Homo sapiens
Symbol: NUDT1
Name: nudix hydrolase 1
Description: Exhibits GTPase activity and nucleoside-triphosphate diphosphatase activity. Involved in DNA protection; dATP catabolic process; and dGTP catabolic process. Localizes to the cytosol; mitochondrial matrix; and nucleus. Biomarker of Alzheimer's disease.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: 2-hydroxy-dATP diphosphatase; 7,8-dihydro-8-oxoguanine triphosphatase; 8-oxo-7,8-dihydrodeoxyguanosine triphosphatase; 8-oxo-7,8-dihydroguanosine triphosphatase; 8-oxo-dGTPase; MTH1; mutt (e. coli) human homolog (8-oxo-dgtpase); mutT human homolog 1; nucleoside diphosphate-linked moiety X motif 1; nucleoside diphosphate-linked moiety X-type motif 1; nudix (nucleoside diphosphate linked moiety X)-type motif 1; nudix motif 1
Mus musculus (house mouse) : Nudt1 (nudix (nucleoside diphosphate linked moiety X)-type motif 1)  MGI  Alliance
Rattus norvegicus (Norway rat) : Nudt1 (nudix hydrolase 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Nudt1 (nudix hydrolase 1)
Pan paniscus (bonobo/pygmy chimpanzee) : NUDT1 (nudix hydrolase 1)
Canis lupus familiaris (dog) : NUDT1 (nudix hydrolase 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Nudt1 (nudix hydrolase 1)
Sus scrofa (pig) : NUDT1 (nudix hydrolase 1)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh3872,242,222 - 2,251,145 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh3772,281,857 - 2,290,780 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3672,248,383 - 2,257,306 (+)NCBINCBI36hg18NCBI36
Build 3472,055,780 - 2,064,021NCBI
Celera72,251,549 - 2,260,471 (+)NCBI
Cytogenetic Map7p22.3NCBI
HuRef72,201,140 - 2,210,062 (+)NCBIHuRef
CHM1_172,281,464 - 2,290,386 (+)NCBICHM1_1
CRA_TCAGchr7v272,330,533 - 2,339,455 (+)NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status



Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on NUDT1
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 731881
Created: 2004-01-12
Species: Homo sapiens
Last Modified: 2019-11-26
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.