Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   
Gene: CDK1 (cyclin dependent kinase 1) Homo sapiens
Analyze
Symbol: CDK1
Name: cyclin dependent kinase 1
Description: Exhibits cyclin binding activity and protein kinase activity. Involved in several processes, including positive regulation of G2/M transition of mitotic cell cycle; positive regulation of mitochondrial ATP synthesis coupled electron transport; and protein phosphorylation. Localizes to several cellular components, including the cyclin B1-CDK1 complex; microtubule cytoskeleton; and midbody. Colocalizes with the mitochondrial matrix. Implicated in breast cancer; cervical cancer; and urinary bladder cancer. Biomarker of breast cancer; gallbladder adenocarcinoma; and transitional cell carcinoma.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: CDC2; CDC28A; cell cycle controller CDC2; cell division control protein 2 homolog; cell division cycle 2 homolog a (s. pombe); cell division cycle 2, G1 to S and G2 to M; cell division protein kinase 1; cyclin-dependent kinase 1; DKFZp686L20222; MGC111195; p34 protein kinase; P34CDC2
Orthologs:
Mus musculus (house mouse) : Cdk1 (cyclin-dependent kinase 1)  MGI  Alliance
Rattus norvegicus (Norway rat) : Cdk1 (cyclin-dependent kinase 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Cdk1 (cyclin dependent kinase 1)
Pan paniscus (bonobo/pygmy chimpanzee) : CDK1 (cyclin dependent kinase 1)
Canis lupus familiaris (dog) : CDK1 (cyclin dependent kinase 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Cdk1 (cyclin dependent kinase 1)
Sus scrofa (pig) : CDK1 (cyclin dependent kinase 1)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381060,778,331 - 60,794,852 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371062,538,089 - 62,554,610 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361062,205,690 - 62,223,930 (+)NCBINCBI36hg18NCBI36
Build 341062,209,916 - 62,223,930NCBI
Celera1055,803,740 - 55,820,255 (+)NCBI
Cytogenetic Map10q21.2NCBI
HuRef1056,527,463 - 56,544,301 (+)NCBIHuRef
CHM1_11062,820,315 - 62,836,829 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
Nomenclature History
 
More on CDK1
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 731889
Created: 2004-01-12
Species: Homo sapiens
Last Modified: 2019-11-26
Status: ACTIVE



NHLBI Logo

RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.