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Gene: DLG1 (discs large MAGUK scaffold protein 1) Homo sapiens
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Symbol: DLG1
Name: discs large MAGUK scaffold protein 1
Description: Exhibits several functions, including L27 domain binding activity; enzyme binding activity; and ion channel binding activity. Involved in several processes, including actin cytoskeleton organization; cytoplasmic microtubule organization; and negative regulation of MAPK cascade. Localizes to several cellular components, including the MPP7-DLG1-LIN7 complex; basolateral plasma membrane; and immunological synapse. Predicted to colocalize with the ionotropic glutamate receptor complex. Implicated in invasive ductal carcinoma. Biomarker of cervix uteri carcinoma in situ.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: discs large homolog 1; discs large homolog 1, scribble cell polarity complex component; discs, large homolog 1; discs, large homolog 1 (Drosophila) transcript variant 6-v1; discs, large homolog 1 (Drosophila) transcript variant 6-v2; discs, large homolog 1 transcript variant 6-v1; discs, large homolog 1 transcript variant 6-v2; disks large homolog 1; dJ1061C18.1.1; DKFZp761P0818; DKFZp781B0426; DLGH1; hdlg; presynaptic protein SAP97; SAP-97; SAP97; synapse-associated protein 97
Orthologs:
Mus musculus (house mouse) : Dlg1 (discs large MAGUK scaffold protein 1)  MGI  Alliance
Rattus norvegicus (Norway rat) : Dlg1 (discs large MAGUK scaffold protein 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Dlg1 (discs large MAGUK scaffold protein 1)
Pan paniscus (bonobo/pygmy chimpanzee) : DLG1 (discs large MAGUK scaffold protein 1)
Canis lupus familiaris (dog) : DLG1 (discs large MAGUK scaffold protein 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Dlg1 (discs large MAGUK scaffold protein 1)
Sus scrofa (pig) : DLG1 (discs large MAGUK scaffold protein 1)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh383197,042,560 - 197,299,321 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh373196,769,431 - 197,026,171 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 363198,253,828 - 198,509,844 (-)NCBINCBI36hg18NCBI36
Build 343198,259,732 - 198,513,757NCBI
Celera3195,354,807 - 195,610,760 (-)NCBI
Cytogenetic Map3q29NCBI
HuRef3194,068,872 - 194,324,699 (-)NCBIHuRef
CHM1_13196,740,135 - 196,996,969 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
Nomenclature History
 
More on DLG1
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 731903
Created: 2004-01-12
Species: Homo sapiens
Last Modified: 2019-11-26
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.