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Gene: PIK3R1 (phosphoinositide-3-kinase regulatory subunit 1) Homo sapiens
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Symbol: PIK3R1
Name: phosphoinositide-3-kinase regulatory subunit 1
Description: Exhibits several functions, including insulin binding activity; phosphotyrosine residue binding activity; and signaling receptor binding activity. Involved in several processes, including phosphatidylinositol 3-kinase signaling; positive regulation of RNA metabolic process; and transmembrane receptor protein tyrosine kinase signaling pathway. Localizes to the cytoplasm. Implicated in several diseases, including astroblastoma; endometrial cancer (multiple); lung small cell carcinoma; primary immunodeficiency disease (multiple); and type 2 diabetes mellitus. Biomarker of astroblastoma; colorectal cancer; lung adenocarcinoma; prostate cancer; and renal cell carcinoma.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: AGM7; GRB1; IMD36; p85; p85-ALPHA; phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha; phosphatidylinositol 3-kinase regulatory subunit alpha; phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 1; phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 1 (p85 alpha); phosphatidylinositol 3-kinase, regulatory, 1; phosphatidylinositol 3-kinase-associated p-85 alpha; phosphoinositide-3-kinase regulatory subunit; phosphoinositide-3-kinase regulatory subunit alpha; phosphoinositide-3-kinase, regulatory subunit 1 (alpha); PI3-kinase regulatory subunit alpha; PI3-kinase subunit p85-alpha; PI3K regulatory subunit alpha; ptdIns-3-kinase regulatory subunit alpha; ptdIns-3-kinase regulatory subunit p85-alpha
Orthologs:
Mus musculus (house mouse) : Pik3r1 (phosphoinositide-3-kinase regulatory subunit 1)  MGI  Alliance
Rattus norvegicus (Norway rat) : Pik3r1 (phosphoinositide-3-kinase regulatory subunit 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Pik3r1 (phosphoinositide-3-kinase regulatory subunit 1)
Pan paniscus (bonobo/pygmy chimpanzee) : PIK3R1 (phosphoinositide-3-kinase regulatory subunit 1)
Canis lupus familiaris (dog) : PIK3R1 (phosphoinositide-3-kinase regulatory subunit 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Pik3r1 (phosphoinositide-3-kinase regulatory subunit 1)
Sus scrofa (pig) : PIK3R1 (phosphoinositide-3-kinase regulatory subunit 1)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38568,215,737 - 68,301,821 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37567,511,584 - 67,597,649 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36567,558,218 - 67,633,405 (+)NCBINCBI36hg18NCBI36
Build 34567,622,250 - 67,633,403NCBI
Celera564,520,829 - 64,597,175 (+)NCBI
Cytogenetic Map5q13.1NCBI
HuRef564,468,818 - 64,555,164 (+)NCBIHuRef
CHM1_1567,511,846 - 67,597,747 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
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References - uncurated

Genomics

Comparative Map Data
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miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
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Clinical Variants

Additional Information

External Database Links
Nomenclature History
 
More on PIK3R1
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 731958
Created: 2004-01-12
Species: Homo sapiens
Last Modified: 2019-11-26
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.