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Gene: DEAF1 (DEAF1 transcription factor) Homo sapiens
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Symbol: DEAF1
Name: DEAF1 transcription factor
Description: Exhibits DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II regulatory region sequence-specific DNA binding activity. Involved in negative regulation of transcription by RNA polymerase II; positive regulation of transcription, DNA-templated; and regulation of mammary gland epithelial cell proliferation. Localizes to the cytoplasm; fibrillar center; and nucleoplasm. Implicated in autosomal dominant non-syndromic intellectual disability 24.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: deaf-1 related transcriptional regulator (nudr); DEAF1, transcription factor; deformed epidermal autoregulatory factor 1 homolog; MRD24; nuclear DEAF-1-related transcriptional regulator; NUDR; SPN; suppressin; zinc finger MYND domain-containing protein 5; ZMYND5
Orthologs:
Mus musculus (house mouse) : Deaf1 (DEAF1, transcription factor)  MGI  Alliance
Rattus norvegicus (Norway rat) : Deaf1 (DEAF1 transcription factor)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Deaf1 (DEAF1 transcription factor)
Pan paniscus (bonobo/pygmy chimpanzee) : DEAF1 (DEAF1 transcription factor)
Canis lupus familiaris (dog) : DEAF1 (DEAF1 transcription factor)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Deaf1 (DEAF1 transcription factor)
Sus scrofa (pig) : DEAF1 (DEAF1 transcription factor)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3811644,220 - 707,083 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh3711644,225 - 695,740 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3611634,225 - 685,740 (-)NCBINCBI36hg18NCBI36
Build 3411634,224 - 685,740NCBI
Cytogenetic Map11p15.5NCBI
HuRef11460,942 - 512,153 (-)NCBIHuRef
CHM1_111643,446 - 694,676 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
Nomenclature History
 
More on DEAF1
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 731970
Created: 2004-01-12
Species: Homo sapiens
Last Modified: 2019-11-26
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.