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Gene: SP1 (Sp1 transcription factor) Homo sapiens
Symbol: SP1
Name: Sp1 transcription factor
CRRD ID: 732035
Description: Exhibits several functions, including DNA-binding transcription activator activity, RNA polymerase II-specific; HMG box domain binding activity; and histone deacetylase binding activity. Involved in several processes, including positive regulation by host of viral transcription; positive regulation of cellular metabolic process; and positive regulation of vascular endothelial cell proliferation. Localizes to nuclear euchromatin; nucleoplasm; and transcription repressor complex.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: specificity protein 1; transcription factor Sp1
Mus musculus (house mouse) : Sp1 (trans-acting transcription factor 1)  MGI  Alliance
Rattus norvegicus (Norway rat) : Sp1 (Sp1 transcription factor)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Sp1 (Sp1 transcription factor)
Pan paniscus (bonobo/pygmy chimpanzee) : SP1 (Sp1 transcription factor)
Canis lupus familiaris (dog) : SP1 (Sp1 transcription factor)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Sp1 (Sp1 transcription factor)
Sus scrofa (pig) : SP1 (Sp1 transcription factor)
Chlorocebus sabaeus (African green monkey) : SP1 (Sp1 transcription factor)
Heterocephalus glaber (naked mole-rat) : Sp1 (Sp1 transcription factor)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38.p13 Ensembl1253,380,176 - 53,416,446 (+)EnsemblGRCh38hg38GRCh38
GRCh381253,380,176 - 53,416,446 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371253,773,979 - 53,810,230 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361252,060,246 - 52,096,497 (+)NCBINCBI36hg18NCBI36
Build 341252,060,245 - 52,096,491NCBI
Celera1253,423,138 - 53,460,427 (+)NCBI
Cytogenetic Map12q13.13NCBI
HuRef1250,814,656 - 50,850,614 (+)NCBIHuRef
CHM1_11253,741,140 - 53,777,425 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
More on SP1
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 732035
Created: 2004-01-12
Species: Homo sapiens
Last Modified: 2020-09-16
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.