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Gene: FAP (fibroblast activation protein alpha) Homo sapiens
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Symbol: FAP
Name: fibroblast activation protein alpha
Description: Exhibits several functions, including integrin binding activity; peptidase activity, acting on L-amino acid peptides; and protein homodimerization activity. Involved in several processes, including endothelial cell migration; negative regulation of extracellular matrix disassembly; and regulation of collagen catabolic process. Localizes to the extracellular space; invadopodium membrane; and lamellipodium.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: 170 kDa melanoma membrane-bound gelatinase; dipeptidyl peptidase FAP; DKFZp686G13158; DPPIV; FAPA; FAPalpha; fibroblast activation protein; fibroblast activation protein, alpha; gelatine degradation protease FAP; integral membrane serine protease; post-proline cleaving enzyme; prolyl endopeptidase FAP; seprase; serine integral membrane protease; SIMP; surface-expressed protease
Orthologs:
Mus musculus (house mouse) : Fap (fibroblast activation protein)  MGI  Alliance
Rattus norvegicus (Norway rat) : Fap (fibroblast activation protein, alpha)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Fap (fibroblast activation protein alpha)
Pan paniscus (bonobo/pygmy chimpanzee) : FAP (fibroblast activation protein alpha)
Canis lupus familiaris (dog) : FAP (fibroblast activation protein alpha)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Fap (fibroblast activation protein alpha)
Sus scrofa (pig) : FAP (fibroblast activation protein alpha)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382162,170,684 - 162,243,472 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh372163,027,194 - 163,100,045 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362162,735,446 - 162,808,291 (-)NCBINCBI36hg18NCBI36
Build 342162,852,708 - 162,925,552NCBI
Celera2156,637,516 - 156,710,361 (-)NCBI
Cytogenetic Map2q24.2NCBI
HuRef2154,909,562 - 154,982,406 (-)NCBIHuRef
CHM1_12163,033,084 - 163,105,931 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
Nomenclature History
 
More on FAP
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 732069
Created: 2004-01-12
Species: Homo sapiens
Last Modified: 2019-11-26
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.