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Gene: FAP (fibroblast activation protein alpha) Homo sapiens
Symbol: FAP
Name: fibroblast activation protein alpha
Description: Exhibits several functions, including integrin binding activity; peptidase activity, acting on L-amino acid peptides; and protein homodimerization activity. Involved in several processes, including endothelial cell migration; negative regulation of extracellular matrix disassembly; and regulation of collagen catabolic process. Localizes to the extracellular space; invadopodium membrane; and lamellipodium.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: 170 kDa melanoma membrane-bound gelatinase; dipeptidyl peptidase FAP; DKFZp686G13158; DPPIV; FAPA; FAPalpha; fibroblast activation protein; fibroblast activation protein, alpha; gelatine degradation protease FAP; integral membrane serine protease; post-proline cleaving enzyme; prolyl endopeptidase FAP; seprase; serine integral membrane protease; SIMP; surface-expressed protease
Mus musculus (house mouse) : Fap (fibroblast activation protein)  MGI  Alliance
Rattus norvegicus (Norway rat) : Fap (fibroblast activation protein, alpha)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Fap (fibroblast activation protein alpha)
Pan paniscus (bonobo/pygmy chimpanzee) : FAP (fibroblast activation protein alpha)
Canis lupus familiaris (dog) : FAP (fibroblast activation protein alpha)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Fap (fibroblast activation protein alpha)
Sus scrofa (pig) : FAP (fibroblast activation protein alpha)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh382162,170,684 - 162,243,472 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh372163,027,194 - 163,100,045 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362162,735,446 - 162,808,291 (-)NCBINCBI36hg18NCBI36
Build 342162,852,708 - 162,925,552NCBI
Celera2156,637,516 - 156,710,361 (-)NCBI
Cytogenetic Map2q24.2NCBI
HuRef2154,909,562 - 154,982,406 (-)NCBIHuRef
CHM1_12163,033,084 - 163,105,931 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status



Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on FAP
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 732069
Created: 2004-01-12
Species: Homo sapiens
Last Modified: 2019-11-26
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.