Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   
Gene: FGD4 (FYVE, RhoGEF and PH domain containing 4) Homo sapiens
Analyze
Symbol: FGD4
Name: FYVE, RhoGEF and PH domain containing 4
Description: Predicted to have guanyl-nucleotide exchange factor activity and small GTPase binding activity. Predicted to be involved in several processes, including filopodium assembly; regulation of GTPase activity; and regulation of cell shape. Predicted to localize to the Golgi apparatus; lamellipodium; and ruffle. Implicated in Charcot-Marie-Tooth disease type 4H.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: actin filament-binding protein frabin; actin-filament binding protein frabin; CMT4H; DKFZp313E1818; DKFZp434K1572; FGD1 family, member 4; FGD1-related F-actin-binding protein; FLJ34370; FLJ42663; FRABP; FYVE, RhoGEF and PH domain-containing protein 4; MGC57222; ZFYVE6; zinc finger FYVE domain-containing protein 6
Orthologs:
Mus musculus (house mouse) : Fgd4 (FYVE, RhoGEF and PH domain containing 4)  MGI  Alliance
Rattus norvegicus (Norway rat) : Fgd4 (FYVE, RhoGEF and PH domain containing 4)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Fgd4 (FYVE, RhoGEF and PH domain containing 4)
Pan paniscus (bonobo/pygmy chimpanzee) : FGD4 (FYVE, RhoGEF and PH domain containing 4)
Canis lupus familiaris (dog) : FGD4 (FYVE, RhoGEF and PH domain containing 4)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Fgd4 (FYVE, RhoGEF and PH domain containing 4)
Sus scrofa (pig) : FGD4 (FYVE, RhoGEF and PH domain containing 4)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381232,399,523 - 32,646,050 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371232,552,518 - 32,798,984 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361232,546,361 - 32,684,940 (+)NCBINCBI36hg18NCBI36
Build 341232,546,360 - 32,684,940NCBI
Celera1212,475,281 - 12,619,210 (+)NCBI
Cytogenetic Map12p11.21NCBI
HuRef1232,407,492 - 32,551,291 (+)NCBIHuRef
CHM1_11232,605,553 - 32,765,483 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
 
More on FGD4
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 732078
Created: 2004-01-12
Species: Homo sapiens
Last Modified: 2019-11-26
Status: ACTIVE



NHLBI Logo

RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.