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Gene: CTH (cystathionine gamma-lyase) Homo sapiens
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Symbol: CTH
Name: cystathionine gamma-lyase
Description: Exhibits carbon-sulfur lyase activity; identical protein binding activity; and pyridoxal phosphate binding activity. Involved in several processes, including cellular protein modification process; cysteine metabolic process; and hydrogen sulfide biosynthetic process. Localizes to the extracellular exosome. Implicated in amino acid metabolic disorder and cystathioninuria.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: cystathionase (cystathionine gamma-lyase); cysteine desulfhydrase; cysteine-protein sulfhydrase; gamma-cystathionase; homoserine deaminase; homoserine dehydratase; MGC9471
Orthologs:
Mus musculus (house mouse) : Cth (cystathionase (cystathionine gamma-lyase))  MGI  Alliance
Rattus norvegicus (Norway rat) : Cth (cystathionine gamma-lyase)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Cth (cystathionine gamma-lyase)
Pan paniscus (bonobo/pygmy chimpanzee) : CTH (cystathionine gamma-lyase)
Canis lupus familiaris (dog) : CTH (cystathionine gamma-lyase)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Cth (cystathionine gamma-lyase)
Sus scrofa (pig) : CTH (cystathionine gamma-lyase)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38 Ensembl170,411,218 - 70,439,851 (+)Ensembl
GRCh38170,411,218 - 70,441,949 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37170,876,901 - 70,905,534 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36170,649,543 - 70,677,841 (+)NCBINCBI36hg18NCBI36
Build 34170,588,975 - 70,617,273NCBI
Celera169,166,835 - 69,195,464 (+)NCBI
Cytogenetic Map1p31.1NCBI
HuRef168,987,754 - 69,016,606 (+)NCBIHuRef
CHM1_1170,992,268 - 71,020,901 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
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Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
Nomenclature History
 
More on CTH
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 732084
Created: 2004-01-12
Species: Homo sapiens
Last Modified: 2019-12-25
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.