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Gene: Cth (cystathionase (cystathionine gamma-lyase)) Mus musculus
Symbol: Cth
Name: cystathionase (cystathionine gamma-lyase)
Description: Exhibits L-cystine L-cysteine-lyase (deaminating) and cystathionine gamma-lyase activity. Involved in several processes, including cellular response to leukemia inhibitory factor; positive regulation of NF-kappaB transcription factor activity; and regulation of signal transduction. Predicted to localize to the cytoplasm. Used to study cystathioninuria. Human ortholog(s) of this gene implicated in amino acid metabolic disorder and cystathioninuria. Is expressed in several structures, including alimentary system; central nervous system; cranium; ear; and genitourinary system. Orthologous to human CTH (cystathionine gamma-lyase); PARTICIPATES IN cystathioninuria pathway; cysteine metabolic pathway; dihydropyrimidine dehydrogenase deficiency pathway; INTERACTS WITH 1,1-dichloroethene; 17alpha-ethynylestradiol; 2,3,7,8-tetrabromodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 0610010I13Rik; AI314617; BC019483; CSE; Cys3; cystathionine gamma-lyase; cysteine-protein sulfhydrase; gamma-cystathionase; MGC28655
Homo sapiens (human) : CTH (cystathionine gamma-lyase)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Cth (cystathionine gamma-lyase)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Cth (cystathionine gamma-lyase)
Pan paniscus (bonobo/pygmy chimpanzee) : CTH (cystathionine gamma-lyase)
Canis lupus familiaris (dog) : CTH (cystathionine gamma-lyase)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Cth (cystathionine gamma-lyase)
Sus scrofa (pig) : CTH (cystathionine gamma-lyase)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38 Ensembl3157,894,248 - 157,925,077 (-)Ensembl
GRCm383157,894,248 - 157,925,081 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv373157,557,212 - 157,588,027 (-)NCBIGRCm37mm9NCBIm37
MGSCv363157,829,541 - 157,860,356 (-)NCBImm8
Celera3164,361,761 - 164,392,686 (-)NCBICelera
Cytogenetic Map3 H4NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Cth
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 732085
Created: 2004-01-12
Species: Mus musculus
Last Modified: 2019-12-25
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.