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Gene: GUCY2C (guanylate cyclase 2C) Homo sapiens
Symbol: GUCY2C
Name: guanylate cyclase 2C
Description: Predicted to have guanylate cyclase activity; natriuretic peptide receptor activity; and peptide hormone binding activity. Predicted to be involved in cGMP biosynthetic process and receptor guanylyl cyclase signaling pathway. Predicted to localize to the plasma membrane. Implicated in congenital diarrhea 6.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: DIAR6; GC-C; guanylyl cyclase C; GUC2C; heat stable enterotoxin receptor; heat-stable enterotoxin receptor; hSTAR; intestinal guanylate cyclase; MECIL; MUCIL; STA receptor; STAR
Mus musculus (house mouse) : Gucy2c (guanylate cyclase 2c)  MGI  Alliance
Rattus norvegicus (Norway rat) : Gucy2c (guanylate cyclase 2C)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Gucy2c (guanylate cyclase 2C)
Pan paniscus (bonobo/pygmy chimpanzee) : GUCY2C (guanylate cyclase 2C)
Canis lupus familiaris (dog) : GUCY2C (guanylate cyclase 2C)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Gucy2c (guanylate cyclase 2C)
Sus scrofa (pig) : GUCY2C (guanylate cyclase 2C)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh381214,612,632 - 14,696,625 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371214,765,566 - 14,849,519 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361214,656,843 - 14,740,696 (-)NCBINCBI36hg18NCBI36
Build 341214,656,842 - 14,740,696NCBI
Celera1219,910,604 - 19,994,546 (-)NCBI
Cytogenetic Map12p12.3NCBI
HuRef1214,534,894 - 14,618,836 (-)NCBIHuRef
CHM1_11214,731,376 - 14,815,291 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status



Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on GUCY2C
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 732111
Created: 2004-01-12
Species: Homo sapiens
Last Modified: 2019-11-26
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.