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Gene: PCSK5 (proprotein convertase subtilisin/kexin type 5) Homo sapiens
Symbol: PCSK5
Name: proprotein convertase subtilisin/kexin type 5
Description: Exhibits serine-type endopeptidase activity. Involved in several processes, including embryonic digestive tract development; peptide metabolic process; and renin secretion into blood stream. Localizes to the Golgi apparatus. Biomarker of colon adenocarcinoma.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: FLJ11149; FLJ16215; hPC6; PC5; PC6; PC6A; prohormone convertase 5; proprotein convertase 5; proprotein convertase 6; proprotein convertase PC5; protease PC6; SPC6; subtilase; subtilisin/kexin-like protease PC5
Mus musculus (house mouse) : Pcsk5 (proprotein convertase subtilisin/kexin type 5)  MGI  Alliance
Rattus norvegicus (Norway rat) : Pcsk5 (proprotein convertase subtilisin/kexin type 5)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Pcsk5 (proprotein convertase subtilisin/kexin type 5)
Pan paniscus (bonobo/pygmy chimpanzee) : PCSK5 (proprotein convertase subtilisin/kexin type 5)
Canis lupus familiaris (dog) : PCSK5 (proprotein convertase subtilisin/kexin type 5)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Pcsk5 (proprotein convertase subtilisin/kexin type 5)
Sus scrofa (pig) : PCSK5 (proprotein convertase subtilisin/kexin type 5)
Chlorocebus sabaeus (green monkey) : PCSK5 (proprotein convertase subtilisin/kexin type 5)
Heterocephalus glaber (naked mole-rat) : Pcsk5 (proprotein convertase subtilisin/kexin type 5)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38 Ensembl975,890,644 - 76,362,975 (+)Ensembl
GRCh38 Ensembl975,890,644 - 76,362,339 (+)Ensembl
GRCh38975,890,644 - 76,362,975 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37978,505,560 - 78,977,255 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36977,695,441 - 77,998,164 (+)NCBINCBI36hg18NCBI36
Build 34975,735,174 - 76,037,889NCBI
Celera949,083,010 - 49,551,972 (+)NCBI
Cytogenetic Map9q21.13NCBI
HuRef948,336,126 - 48,806,234 (+)NCBIHuRef
CHM1_1978,651,993 - 79,121,401 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
More on PCSK5
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 732125
Created: 2004-01-12
Species: Homo sapiens
Last Modified: 2020-01-28
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.