Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   
Gene: Txnip (thioredoxin interacting protein) Mus musculus
Symbol: Txnip
Name: thioredoxin interacting protein
Description: Exhibits enzyme inhibitor activity. Involved in several processes, including negative regulation of transcription by RNA polymerase II; platelet-derived growth factor receptor signaling pathway; and protein import into nucleus. Localizes to the cytoplasm. Used to study Reye syndrome and hepatocellular carcinoma. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Orthologous to human TXNIP (thioredoxin interacting protein); INTERACTS WITH (-)-anisomycin; (S)-nicotine; 17beta-estradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 1200008J08Rik; AA682105; hyperlipidemia 1; Hyplip1; Tbp-2; THIF; thioredoxin binding protein-2; thioredoxin-interacting protein; upregulated by 1,25-dihydroxyvitamin D-3; VDUP1; vitamin D3 up-regulated protein 1
Homo sapiens (human) : TXNIP (thioredoxin interacting protein)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Txnip (thioredoxin interacting protein)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Txnip (thioredoxin interacting protein)
Pan paniscus (bonobo/pygmy chimpanzee) : TXNIP (thioredoxin interacting protein)
Canis lupus familiaris (dog) : TXNIP (thioredoxin interacting protein)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Txnip (thioredoxin interacting protein)
Sus scrofa (pig) : TXNIP (thioredoxin interacting protein)
Chlorocebus sabaeus (African green monkey) : TXNIP (thioredoxin interacting protein)
Heterocephalus glaber (naked mole-rat) : Txnip (thioredoxin interacting protein)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38 Ensembl396,557,957 - 96,561,883 (+)EnsemblGRCm38mm10GRCm38
GRCm38396,557,957 - 96,561,857 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv37396,361,880 - 96,365,780 (+)NCBIGRCm37mm9NCBIm37
MGSCv36396,643,362 - 96,647,271 (+)NCBImm8
Celera397,964,967 - 97,968,875 (+)NCBICelera
Cytogenetic Map3F2.1NCBI
cM Map341.93NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Txnip
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 732141
Created: 2004-01-12
Species: Mus musculus
Last Modified: 2020-03-25
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.