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Gene: Mthfd1 (methylenetetrahydrofolate dehydrogenase (NADP+ dependent), methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthase) Mus musculus
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Symbol: Mthfd1
Name: methylenetetrahydrofolate dehydrogenase (NADP+ dependent), methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthase
Description: Exhibits formate-tetrahydrofolate ligase activity and methylenetetrahydrofolate dehydrogenase (NAD+) activity. Involved in several processes, including carboxylic acid metabolic process; neural tube closure; and neutrophil homeostasis. Localizes to the mitochondrion. Human ortholog(s) of this gene implicated in Down syndrome; cleft lip; cleft palate; neural tube defect (multiple); and tetralogy of Fallot. Is expressed in several structures, including alimentary system; brain; genitourinary system; respiratory system; and sensory organ. Orthologous to human MTHFD1 (methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1).
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: C-1-tetrahydrofolate synthase, cytoplasmic; C1-tetrahydrofolate synthase; C1-THF synthase; Dcs; E430024A07Rik; Mthfd
Orthologs:
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm38 Ensembl1276,255,298 - 76,319,803 (+)EnsemblGRCm38mm10GRCm38
GRCm381276,254,406 - 76,319,820 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv371277,356,219 - 77,420,807 (+)NCBIGRCm37mm9NCBIm37
MGSCv361277,174,248 - 77,238,643 (+)NCBImm8
Celera1277,346,103 - 77,410,765 (+)NCBICelera
Cytogenetic Map12 C3NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Cell Lines
Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters

Additional Information

External Database Links
 
More on Mthfd1
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 732148
Created: 2004-01-12
Species: Mus musculus
Last Modified: 2019-11-27
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.