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Gene: STAT1 (signal transducer and activator of transcription 1) Homo sapiens
Symbol: STAT1
Name: signal transducer and activator of transcription 1
Description: Exhibits several functions, including DNA-binding transcription factor binding activity; RNA polymerase II regulatory region sequence-specific DNA binding activity; and enzyme binding activity. Involved in several processes, including cellular response to cytokine stimulus; macrophage derived foam cell differentiation; and negative regulation by virus of viral protein levels in host cell. Localizes to several cellular components, including the cytosol; nuclear lumen; and perinuclear region of cytoplasm. Implicated in breast carcinoma; primary immunodeficiency disease; and prostate adenocarcinoma. Biomarker of angiomyolipoma; breast cancer; lymphangioleiomyomatosis; and nephroblastoma.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: CANDF7; DKFZp686B04100; IMD31A; IMD31B; IMD31C; ISGF-3; signal transducer and activator of transcription 1, 91kD; signal transducer and activator of transcription 1, 91kDa; signal transducer and activator of transcription 1-alpha/beta; signal transducer and activator of transcription-1; STAT91; transcription factor ISGF-3 components p91/p84
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh382190,968,989 - 191,014,250 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh372191,833,762 - 191,878,976 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362191,542,121 - 191,587,181 (-)NCBINCBI36hg18NCBI36
Build 342191,665,769 - 191,704,442NCBI
Celera2185,428,361 - 185,473,577 (-)NCBI
Cytogenetic Map2q32.2NCBI
HuRef2183,693,413 - 183,738,626 (-)NCBIHuRef
CHM1_12191,839,599 - 191,884,801 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Candidate Gene Status
Comparative Map Data
Position Markers
miRNA Target Status



Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on STAT1
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 732184
Created: 2004-01-12
Species: Homo sapiens
Last Modified: 2019-11-26
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.