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Gene: ABCA2 (ATP binding cassette subfamily A member 2) Homo sapiens
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Symbol: ABCA2
Name: ATP binding cassette subfamily A member 2
Description: Exhibits several functions, including ATP binding activity; ceramide floppase activity; and endopeptidase regulator activity. Involved in several processes, including negative regulation of cholesterol transport; negative regulation of lipid metabolic process; and regulation of protein metabolic process. Localizes to several cellular components, including the endosome; integral component of membrane; and lysosome.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: ABC2; ATP-binding cassette 2; ATP-binding cassette sub-family A member 2; ATP-binding cassette transporter 2; ATP-binding cassette, sub-family A (ABC1), member 2; ATP-binding cassette, sub-family A, member 2; MGC129761
Orthologs:
Mus musculus (house mouse) : Abca2 (ATP-binding cassette, sub-family A (ABC1), member 2)  MGI  Alliance
Rattus norvegicus (Norway rat) : Abca2 (ATP binding cassette subfamily A member 2)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Abca2 (ATP binding cassette subfamily A member 2)
Pan paniscus (bonobo/pygmy chimpanzee) : ABCA2 (ATP binding cassette subfamily A member 2)
Canis lupus familiaris (dog) : ABCA2 (ATP binding cassette subfamily A member 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Abca2 (ATP binding cassette subfamily A member 2)
Sus scrofa (pig) : ABCA2 (ATP binding cassette subfamily A member 2)
Chlorocebus sabaeus (African green monkey) : ABCA2 (ATP binding cassette subfamily A member 2)
Heterocephalus glaber (naked mole-rat) : Abca2 (ATP binding cassette subfamily A member 2)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38 Ensembl9137,007,234 - 137,028,922 (-)Ensembl
GRCh389137,007,234 - 137,028,922 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh379139,901,686 - 139,923,374 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 369139,021,507 - 139,043,195 (-)NCBINCBI36hg18NCBI36
Build 349137,177,522 - 137,199,211NCBI
Celera9110,414,121 - 110,431,191 (-)NCBI
Cytogenetic Map9q34.3NCBI
HuRef9109,360,841 - 109,382,226 (-)NCBIHuRef
CHM1_19140,050,436 - 140,072,137 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
Nomenclature History
 
More on ABCA2
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 732200
Created: 2004-01-12
Species: Homo sapiens
Last Modified: 2019-12-25
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.