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Gene: Myo7a (myosin VIIA) Mus musculus
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Symbol: Myo7a
Name: myosin VIIA
Description: Exhibits protein domain specific binding activity. Involved in several processes, including animal organ morphogenesis; phagolysosome assembly; and pigment granule transport. Localizes to several cellular components, including the melanosome; photoreceptor connecting cilium; and stereocilium base. Used to study Usher syndrome type 1 and autosomal recessive nonsyndromic deafness 2. Human ortholog(s) of this gene implicated in Leber congenital amaurosis; Usher syndrome (multiple); auditory system disease (multiple); and congenital nystagmus. Is expressed in central nervous system; inner ear; olfactory epithelium; and retina. Orthologous to human MYO7A (myosin VIIA); PARTICIPATES IN auditory mechanotransduction pathway; retinitis pigmentosa pathway; INTERACTS WITH 1,1-dichloroethene; 2,3,7,8-tetrachlorodibenzodioxine; 3,3',5,5'-tetrabromobisphenol A.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: Hdb; motor protein; Myo7; myosin-VIIa; nmf371; polka; sh-1; sh1; shaker 1; unconventional myosin-VIIa; USH1B
Orthologs:
Homo sapiens (human) : MYO7A (myosin VIIA)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Myo7a (myosin VIIA)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Myo7a (myosin VIIA)
Pan paniscus (bonobo/pygmy chimpanzee) : MYO7A (myosin VIIA)
Canis lupus familiaris (dog) : MYO7A (myosin VIIA)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Myo7a (myosin VIIA)
Sus scrofa (pig) : MYO7A (myosin VIIA)
Chlorocebus sabaeus (green monkey) : MYO7A (myosin VIIA)
Heterocephalus glaber (naked mole-rat) : Myo7a (myosin VIIA)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm38 Ensembl798,051,060 - 98,119,524 (-)Ensembl
GRCm38798,051,054 - 98,119,522 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv377105,199,570 - 105,268,003 (-)NCBIGRCm37mm9NCBIm37
MGSCv36797,926,593 - 97,992,926 (-)NCBImm8
Celera798,371,622 - 98,440,211 (-)NCBICelera
Cytogenetic Map7 E1NCBI
cM Map753.57NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters

Additional Information

External Database Links
 
More on Myo7a
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 732207
Created: 2004-01-12
Species: Mus musculus
Last Modified: 2020-01-07
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.