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Gene: GSR (glutathione-disulfide reductase) Homo sapiens
Symbol: GSR
Name: glutathione-disulfide reductase
Description: Predicted to have flavin adenine dinucleotide binding activity and glutathione-disulfide reductase activity. Predicted to be involved in cell redox homeostasis; cellular response to oxidative stress; and glutathione metabolic process. Localizes to extracellular exosome. Implicated in macular degeneration. Biomarker of several diseases, including artery disease (multiple); cataract (multiple); diabetic angiopathy; hematologic cancer (multiple); and hemolytic anemia (multiple).
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: epididymis luminal protein 75; epididymis secretory sperm binding protein Li 122m; glutathione reductase; glutathione reductase, mitochondrial; glutathione S-reductase; GR; GRase; GSRD; HEL-75; HEL-S-122m; MGC78522
Mus musculus (house mouse) : Gsr (glutathione reductase)  MGI  Alliance
Rattus norvegicus (Norway rat) : Gsr (glutathione-disulfide reductase)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Gsr (glutathione-disulfide reductase)
Pan paniscus (bonobo/pygmy chimpanzee) : GSR (glutathione-disulfide reductase)
Canis lupus familiaris (dog) : GSR (glutathione-disulfide reductase)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Gsr (glutathione-disulfide reductase)
Sus scrofa (pig) : GSR (glutathione-disulfide reductase)
Chlorocebus sabaeus (African green monkey) : GSR (glutathione-disulfide reductase)
Heterocephalus glaber (naked mole-rat) : Gsr (glutathione-disulfide reductase)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38 Ensembl830,678,066 - 30,727,846 (-)EnsemblGRCh38hg38GRCh38
GRCh38830,678,061 - 30,727,999 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37830,535,578 - 30,585,486 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36830,655,977 - 30,704,985 (-)NCBINCBI36hg18NCBI36
Build 34830,655,976 - 30,704,985NCBI
Celera829,494,968 - 29,543,967 (-)NCBI
Cytogenetic Map8p12NCBI
HuRef829,080,197 - 29,130,251 (-)NCBIHuRef
CHM1_1830,737,741 - 30,787,638 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History