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Gene: NR3C1 (nuclear receptor subfamily 3 group C member 1) Homo sapiens
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Symbol: NR3C1
Name: nuclear receptor subfamily 3 group C member 1
Description: Exhibits several functions, including DNA-binding transcription factor activity, RNA polymerase II-specific; Hsp90 protein binding activity; and transcription regulatory region DNA binding activity. Involved in several processes, including cellular response to dexamethasone stimulus; cellular response to transforming growth factor beta stimulus; and regulation of transcription by RNA polymerase II. Localizes to the cytosol; nuclear speck; and protein-containing complex. Implicated in several diseases, including anorexia nervosa; lung disease (multiple); major depressive disorder; obesity; and renal cell carcinoma. Biomarker of several diseases, including lung disease (multiple); lupus nephritis; nephrotic syndrome (multiple); obstructive sleep apnea; and primary biliary cirrhosis.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: GCCR; GCR; GCRST; glucocorticoid nuclear receptor variant 1; glucocorticoid receptor; GR; GRL; nuclear receptor subfamily 3 group C member 1 variant DL-1; nuclear receptor subfamily 3 group C member 1 variant hGR-B(54); nuclear receptor subfamily 3 group C member 1 variant hGR-B(77); nuclear receptor subfamily 3 group C member 1 variant hGR-B(93); nuclear receptor subfamily 3 group C member 1 variant NS-1; nuclear receptor subfamily 3, group c, member 1; nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
Orthologs:
Mus musculus (house mouse) : Nr3c1 (nuclear receptor subfamily 3, group C, member 1)  MGI  Alliance
Rattus norvegicus (Norway rat) : Nr3c1 (nuclear receptor subfamily 3, group C, member 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Nr3c1 (nuclear receptor subfamily 3 group C member 1)
Pan paniscus (bonobo/pygmy chimpanzee) : NR3C1 (nuclear receptor subfamily 3 group C member 1)
Canis lupus familiaris (dog) : NR3C1 (nuclear receptor subfamily 3 group C member 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Nr3c1 (nuclear receptor subfamily 3 group C member 1)
Sus scrofa (pig) : NR3C1 (nuclear receptor subfamily 3 group C member 1)
more info ...
Related Pseudogenes: NR3C1P1  
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh385143,277,931 - 143,435,512 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh375142,657,496 - 143,113,322 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 365142,637,689 - 142,795,270 (-)NCBINCBI36hg18NCBI36
Build 345142,639,324 - 142,763,087NCBI
Celera5138,738,770 - 138,896,297 (-)NCBI
Cytogenetic Map5q31.3NCBI
HuRef5137,804,733 - 137,962,312 (-)NCBIHuRef
CHM1_15142,091,205 - 142,248,804 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
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