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Cellular Component
Molecular Function

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![]() Biological Process Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | adaptive immune response | | IBA | MGI:MGI:102960 more ... | 2290271 | (PMID:21873635) | GO_Central | PMID:21873635 | B cell receptor signaling pathway | | IDA | | 2290271 | (PMID:10518561) | UniProtKB | PMID:10518561 | B cell receptor signaling pathway | | IBA | PANTHER:PTN000700360, UniProtKB:P42680 | 2290271 | (PMID:21873635) | GO_Central | PMID:21873635 | cytokine-mediated signaling pathway | | TAS | | 2290271 | | Reactome | Reactome:R-HSA-512988 | Fc-epsilon receptor signaling pathway | | TAS | | 2290271 | | Reactome | Reactome:R-HSA-2454202 | integrin-mediated signaling pathway | | IDA | | 2290271 | (PMID:9652744) | UniProtKB | PMID:9652744 | integrin-mediated signaling pathway | | IBA | PANTHER:PTN000700439, UniProtKB:P42680 | 2290271 | (PMID:21873635) | GO_Central | PMID:21873635 | intracellular signal transduction | | IEA | InterPro:IPR001562 | 2290271 | | InterPro | GO_REF:0000002 | peptidyl-tyrosine autophosphorylation | | IMP | | 2290271 | (PMID:10518561) | BHF-UCL | PMID:10518561 | peptidyl-tyrosine autophosphorylation | | IBA | PANTHER:PTN001231474, UniProtKB:P42680 | 2290271 | (PMID:21873635) | GO_Central | PMID:21873635 | peptidyl-tyrosine phosphorylation | | IDA | | 2290271 | (PMID:10518561) | BHF-UCL | PMID:10518561 | positive regulation of peptidyl-tyrosine phosphorylation | | IDA | | 2290271 | (PMID:10518561) | BHF-UCL | PMID:10518561 | protein phosphorylation | | TAS | | 2290271 | (PMID:7934162) | PINC | PMID:7934162 | protein phosphorylation | | IEA | InterPro:IPR001245 | 2290271 | | InterPro | GO_REF:0000002 | regulation of platelet activation | | IDA | | 2290271 | (PMID:9299487), (PMID:9652744) | UniProtKB | PMID:9299487, PMID:9652744 | regulation of platelet activation | | IBA | PANTHER:PTN000700439, UniProtKB:P42680 | 2290271 | (PMID:21873635) | GO_Central | PMID:21873635 | T cell receptor signaling pathway | | IBA | MGI:MGI:102960 more ... | 2290271 | (PMID:21873635) | GO_Central | PMID:21873635 | tissue regeneration | | IBA | PANTHER:PTN000700439, RGD:620973 | 2290271 | (PMID:21873635) | GO_Central | PMID:21873635 | |
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1. | GOA_HUMAN data from the GO Consortium |
2. | Pipeline to import KEGG annotations from KEGG into RGD |
3. | Pipeline to import Pathway Interaction Database annotations from NCI into RGD |
4. | RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations |
5. | RGD automated import pipeline for gene-chemical interactions |
PubMed | 2284097 7526158 7651724 7934162 8621063 8629002 8630736 8632917 8892607 9178903 9299487 9341160 9446655 9473212 9652744 9872994 10382746 10518561 10647781 10795735 10823839 11013262 11071635 11328862 11489907 11598012 11716489 11825908 11940595 12049818 12445832 12477932 12515866 12573241 14614854 14993283 15184383 15355990 15492005 15588985 16273093 16964398 18029348 18171525 18512796 18564921 19167335 19380743 19393603 19807924 19883687 19913121 19953087 20098747 20230531 20379614 20628086 21706016 21873635 22581839 23128233 23260110 24390342 24722985 24728074 26344197 26496610 27382052 27503909 28631381 28935395 29513927 29991678 31474037 |
TEC (Homo sapiens - human) |
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Tec (Mus musculus - house mouse) |
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Tec (Rattus norvegicus - Norway rat) |
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Tec (Chinchilla lanigera - long-tailed chinchilla) |
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TEC (Pan paniscus - bonobo/pygmy chimpanzee) |
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TEC (Canis lupus familiaris - dog) |
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Tec (Ictidomys tridecemlineatus - thirteen-lined ground squirrel) |
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TEC (Sus scrofa - pig) |
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RH70608 |
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G34338 |
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SHGC-86308 |
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SHGC-111508 |
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RW11 |
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TEC_8671 |
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D4S2738 |
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D4S3131 |
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D4S518 |
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SHGC-51527 |
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The detailed report is available here: | ![]() | Full Report | ![]() | CSV | ![]() | TAB | ![]() | Printer |
miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/). For more information about miRGate, see PMID:25858286 or access the full paper here. |
RefSeq Transcripts | NM_003215 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles |
XM_011513737 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
XM_011513741 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
XM_017008569 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
XM_024454193 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
XR_001741318 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
XR_001741319 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
XR_925160 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
GenBank Nucleotide | AC079118 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles |
AC098873 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
AH005334 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
BC101711 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
BC101713 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
BC143487 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
CH471069 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
D29767 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles |
RefSeq Acc Id: | NM_003215 ⟹ NP_003206 | |||||||||||||||||||||||||||||
RefSeq Status: | REVIEWED | |||||||||||||||||||||||||||||
Type: | CODING | |||||||||||||||||||||||||||||
Position: |
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Sequence: |
ACCTCGCAGTCTCCCCAGGTCCGCCCAGCAGCCGCGCTTCAGCCAGAATACTGGGATCTTCAGThide sequence |
RefSeq Acc Id: | XM_011513737 ⟹ XP_011512039 | |||||||||
RefSeq Status: | ||||||||||
Type: | CODING | |||||||||
Position: |
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Sequence: |
CCCTTAAACTACAAAGAGAGACTTTTTGTACTTACAAAGTCCATGCTAACCTACTATGAGGGTChide sequence |
RefSeq Acc Id: | XM_011513741 ⟹ XP_011512043 | |||||||||
RefSeq Status: | ||||||||||
Type: | CODING | |||||||||
Position: |
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Sequence: |
AATACTGGGATCTTCAGTGGCAGGAGGAGTAATCAGAAGACGGAGATGAATTTTAACACTATTThide sequence |
RefSeq Acc Id: | XM_017008569 ⟹ XP_016864058 | |||||||||
RefSeq Status: | ||||||||||
Type: | CODING | |||||||||
Position: |
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Sequence: |
GGGAGGGCAGTCCTCCATCTCCGGGTTGCATGAGGCAGGAATGGAGTCAGGCAGAGAGAGAAAAhide sequence |
RefSeq Acc Id: | XM_024454193 ⟹ XP_024309961 | |||||||||
RefSeq Status: | ||||||||||
Type: | CODING | |||||||||
Position: |
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Sequence: |
GCTTTGCTCTGGACTCTGGGGCGCTAGGCTCCGGACTCCGCGGCGCAGACTGCACCTCGCAGTChide sequence |
RefSeq Acc Id: | XR_001741318 | |||||||||
RefSeq Status: | ||||||||||
Type: | NON-CODING | |||||||||
Position: |
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Sequence: |
AATACTGGGATCTTCAGTGGCAGGAGGAGTAATCAGAAGACGGAGATGAATTTTAACACTATTThide sequence |
RefSeq Acc Id: | XR_001741319 | |||||||||
RefSeq Status: | ||||||||||
Type: | NON-CODING | |||||||||
Position: |
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Sequence: |
GGGCGGGGCGGGGCGCTTTGCTCTGGACTCTGGGGCGCTAGGCTCCGGACTCCGCGGCGCAGAChide sequence |
RefSeq Acc Id: | XR_925160 | |||||||||
RefSeq Status: | ||||||||||
Type: | NON-CODING | |||||||||
Position: |
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Sequence: |
AATACTGGGATCTTCAGTGGCAGGAGGAGTAATCAGAAGACGGAGATGAATTTTAACACTATTThide sequence |
Protein RefSeqs | NP_003206 | (Get FASTA) | NCBI Sequence Viewer |
XP_011512039 | (Get FASTA) | NCBI Sequence Viewer | |
XP_011512043 | (Get FASTA) | NCBI Sequence Viewer | |
XP_016864058 | (Get FASTA) | NCBI Sequence Viewer | |
XP_024309961 | (Get FASTA) | NCBI Sequence Viewer | |
GenBank Protein | AAB60411 | (Get FASTA) | NCBI Sequence Viewer |
AAI01712 | (Get FASTA) | NCBI Sequence Viewer | |
AAI01714 | (Get FASTA) | NCBI Sequence Viewer | |
AAI43488 | (Get FASTA) | NCBI Sequence Viewer | |
BAA06171 | (Get FASTA) | NCBI Sequence Viewer | |
EAW93054 | (Get FASTA) | NCBI Sequence Viewer | |
EAW93055 | (Get FASTA) | NCBI Sequence Viewer | |
P42680 | (Get FASTA) | NCBI Sequence Viewer |
RefSeq Acc Id: | NP_003206 ⟸ NM_003215 |
- UniProtKB: | P42680 (UniProtKB/Swiss-Prot) |
- Sequence: |
MNFNTILEEILIKRSQQKKKTSPLNYKERLFVLTKSMLTYYEGRAEKKYRKGFIDVSKIKCVEIhide sequence |
RefSeq Acc Id: | XP_011512039 ⟸ XM_011513737 |
- Peptide Label: | isoform X2 |
- Sequence: |
MKSGNSIHHQKKYRKGFIDVSKIKCVEIVKNDDGVIPCQNKYPFQVVHDANTLYIFAPSPQSRDhide sequence |
RefSeq Acc Id: | XP_011512043 ⟸ XM_011513741 |
- Peptide Label: | isoform X3 |
- Sequence: |
MNFNTILEEILIKRSQQKKKTSPLNYKERLFVLTKSMLTYYEGRAEKKYRKGFIDVSKIKCVEIhide sequence |
RefSeq Acc Id: | XP_016864058 ⟸ XM_017008569 |
- Peptide Label: | isoform X4 |
- Sequence: |
MIKYHPKFWTDGSYQCCRQTEKLAPGCEKYNLFESSIRKALPPAPETKKRRPPPPIPLEEEDNShide sequence |
RefSeq Acc Id: | XP_024309961 ⟸ XM_024454193 |
- Peptide Label: | isoform X1 |
- Sequence: |
MNFNTILEEILIKRSQQKKKTSPLNYKERLFVLTKSMLTYYEGRAEKKYRKGFIDVSKIKCVEIhide sequence |
RGD ID: | 6802652 | |||||||||
Promoter ID: | HG_KWN:48183 | |||||||||
Type: | CpG-Island | |||||||||
SO ACC ID: | SO:0000170 | |||||||||
Source: | MPROMDB | |||||||||
Tissues & Cell Lines: | CD4+TCell, CD4+TCell_12Hour, HeLa_S3, K562, Lymphoblastoid, NB4 | |||||||||
Transcripts: | OTTHUMT00000250492 | |||||||||
Position: |
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RGD ID: | 6867370 | |||||||||
Promoter ID: | EPDNEW_H6850 | |||||||||
Type: | initiation region | |||||||||
Name: | TEC_1 | |||||||||
Description: | tec protein tyrosine kinase | |||||||||
SO ACC ID: | SO:0000170 | |||||||||
Source: | EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/) | |||||||||
Experiment Methods: | Single-end sequencing. | |||||||||
Position: |
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Name | Type | Condition(s) | Position(s) | Clinical significance |
GRCh38/hg38 4p13-q13.1(chr4:44356201-62245882)x3 | copy number gain | Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000050683]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000050683]|See cases [RCV000050683] | Chr4:44356201..62245882 [GRCh38] Chr4:44358218..63111600 [GRCh37] Chr4:44052975..62794195 [NCBI36] Chr4:4p13-q13.1 |
pathogenic |
GRCh38/hg38 4p13-11(chr4:44577678-49081273)x3 | copy number gain | Global developmental delay [RCV000051770]|See cases [RCV000051770] | Chr4:44577678..49081273 [GRCh38] Chr4:44579695..49083290 [GRCh37] Chr4:44274452..48778047 [NCBI36] Chr4:4p13-11 |
pathogenic |
NM_003215.2(TEC):c.1526G>A (p.Gly509Glu) | single nucleotide variant | Malignant melanoma [RCV000061003] | Chr4:48141364 [GRCh38] Chr4:48143381 [GRCh37] Chr4:47838138 [NCBI36] Chr4:4p12 |
not provided |
NM_003215.2(TEC):c.138+25953G>T | single nucleotide variant | Lung cancer [RCV000094863] | Chr4:48202524 [GRCh38] Chr4:48204541 [GRCh37] Chr4:4p11 |
uncertain significance |
NM_003215.2(TEC):c.138+20478G>T | single nucleotide variant | Lung cancer [RCV000094864] | Chr4:48207999 [GRCh38] Chr4:48210016 [GRCh37] Chr4:4p11 |
uncertain significance |
GRCh38/hg38 4p14-11(chr4:40496476-49579850)x3 | copy number gain | See cases [RCV000134946] | Chr4:40496476..49579850 [GRCh38] Chr4:40498493..49581867 [GRCh37] Chr4:40193250..49276624 [NCBI36] Chr4:4p14-11 |
pathogenic |
GRCh38/hg38 4p12-11(chr4:47383124-48851860)x3 | copy number gain | See cases [RCV000138576] | Chr4:47383124..48851860 [GRCh38] Chr4:47385141..48853877 [GRCh37] Chr4:47079898..48548634 [NCBI36] Chr4:4p12-11 |
uncertain significance |
GRCh37/hg19 4p14-11(chr4:38532827-49064044)x3 | copy number gain | See cases [RCV000240190] | Chr4:38532827..49064044 [GRCh37] Chr4:4p14-11 |
pathogenic |
GRCh37/hg19 4p16.3-11(chr4:12440-49064044)x3 | copy number gain | See cases [RCV000240562] | Chr4:12440..49064044 [GRCh37] Chr4:4p16.3-11 |
pathogenic |
GRCh37/hg19 4p16.3-11(chr4:68345-49089361)x3 | copy number gain | See cases [RCV000449078] | Chr4:68345..49089361 [GRCh37] Chr4:4p16.3-11 |
pathogenic |
GRCh37/hg19 4p16.3-11(chr4:68345-49093788)x3 | copy number gain | See cases [RCV000446451] | Chr4:68345..49093788 [GRCh37] Chr4:4p16.3-11 |
pathogenic |
GRCh37/hg19 4p16.3-q35.2(chr4:12440-190904441)x3 | copy number gain | See cases [RCV000446653] | Chr4:12440..190904441 [GRCh37] Chr4:4p16.3-q35.2 |
pathogenic |
GRCh37/hg19 4p16.3-q35.2(chr4:68346-190957473) | copy number gain | See cases [RCV000510453] | Chr4:68346..190957473 [GRCh37] Chr4:4p16.3-q35.2 |
pathogenic |
GRCh37/hg19 4p16.3-q13.1(chr4:68345-66440622)x3 | copy number gain | See cases [RCV000511193] | Chr4:68345..66440622 [GRCh37] Chr4:4p16.3-q13.1 |
pathogenic |
GRCh37/hg19 4p16.3-q35.2(chr4:68346-190957473)x3 | copy number gain | See cases [RCV000512241] | Chr4:68346..190957473 [GRCh37] Chr4:4p16.3-q35.2 |
pathogenic |
GRCh37/hg19 4p16.3-11(chr4:68345-49089361)x3 | copy number gain | not provided [RCV000682363] | Chr4:68345..49089361 [GRCh37] Chr4:4p16.3-11 |
pathogenic |
GRCh37/hg19 4p12(chr4:47828849-48182073)x1 | copy number loss | not provided [RCV000682399] | Chr4:47828849..48182073 [GRCh37] Chr4:4p12 |
uncertain significance |
GRCh37/hg19 4p16.3-q35.2(chr4:49450-190915650)x3 | copy number gain | not provided [RCV000743155] | Chr4:49450..190915650 [GRCh37] Chr4:4p16.3-q35.2 |
pathogenic |
GRCh37/hg19 4p16.3-q35.2(chr4:49450-190963766)x3 | copy number gain | not provided [RCV000743156] | Chr4:49450..190963766 [GRCh37] Chr4:4p16.3-q35.2 |
pathogenic |
GRCh37/hg19 4p16.3-11(chr4:1356924-49659859)x3 | copy number gain | not provided [RCV000743201] | Chr4:1356924..49659859 [GRCh37] Chr4:4p16.3-11 |
pathogenic |
GRCh37/hg19 4p16.3-q35.2(chr4:11525-191028879)x3 | copy number gain | not provided [RCV000743147] | Chr4:11525..191028879 [GRCh37] Chr4:4p16.3-q35.2 |
pathogenic |
GRCh37/hg19 4p12-11(chr4:47951905-48323818)x3 | copy number gain | not provided [RCV000849578] | Chr4:47951905..48323818 [GRCh37] Chr4:4p12-11 |
uncertain significance |
Database | Acc Id | Source(s) |
AGR Gene | HGNC:11719 | AgrOrtholog |
COSMIC | TEC | COSMIC |
Ensembl Genes | ENSG00000135605 | ENTREZGENE, UniProtKB/Swiss-Prot |
Ensembl Protein | ENSP00000370912 | ENTREZGENE, UniProtKB/Swiss-Prot |
ENSP00000424365 | UniProtKB/TrEMBL | |
ENSP00000424567 | UniProtKB/TrEMBL | |
Ensembl Transcript | ENST00000381501 | ENTREZGENE, UniProtKB/Swiss-Prot |
ENST00000505452 | UniProtKB/TrEMBL | |
ENST00000515146 | UniProtKB/TrEMBL | |
Gene3D-CATH | 2.30.29.30 | UniProtKB/Swiss-Prot |
3.30.505.10 | UniProtKB/Swiss-Prot | |
GTEx | ENSG00000135605 | GTEx |
HGNC ID | HGNC:11719 | ENTREZGENE |
Human Proteome Map | TEC | Human Proteome Map |
InterPro | Kinase-like_dom_sf | UniProtKB/Swiss-Prot |
PH-like_dom_sf | UniProtKB/Swiss-Prot | |
PH_domain | UniProtKB/Swiss-Prot | |
Prot_kinase_dom | UniProtKB/Swiss-Prot | |
Protein_kinase_ATP_BS | UniProtKB/Swiss-Prot | |
Ser-Thr/Tyr_kinase_cat_dom | UniProtKB/Swiss-Prot | |
SH2 | UniProtKB/Swiss-Prot | |
SH2_dom_sf | UniProtKB/Swiss-Prot | |
SH3-like_dom_sf | UniProtKB/Swiss-Prot | |
SH3_domain | UniProtKB/Swiss-Prot | |
Tec_SH3 | UniProtKB/Swiss-Prot | |
Tyr_kinase_AS | UniProtKB/Swiss-Prot | |
Tyr_kinase_cat_dom | UniProtKB/Swiss-Prot | |
Znf_Btk_motif | UniProtKB/Swiss-Prot | |
KEGG Report | hsa:7006 | UniProtKB/Swiss-Prot |
NCBI Gene | 7006 | ENTREZGENE |
OMIM | 600583 | OMIM |
Pfam | BTK | UniProtKB/Swiss-Prot |
PF00169 | UniProtKB/Swiss-Prot | |
Pkinase_Tyr | UniProtKB/Swiss-Prot | |
SH2 | UniProtKB/Swiss-Prot | |
SH3_1 | UniProtKB/Swiss-Prot | |
PharmGKB | PA36436 | PharmGKB |
PRINTS | SH2DOMAIN | UniProtKB/Swiss-Prot |
SH3DOMAIN | UniProtKB/Swiss-Prot | |
TECBTKDOMAIN | UniProtKB/Swiss-Prot | |
TYRKINASE | UniProtKB/Swiss-Prot | |
PROSITE | PH_DOMAIN | UniProtKB/Swiss-Prot |
PROTEIN_KINASE_ATP | UniProtKB/Swiss-Prot | |
PROTEIN_KINASE_DOM | UniProtKB/Swiss-Prot | |
PROTEIN_KINASE_TYR | UniProtKB/Swiss-Prot | |
SH2 | UniProtKB/Swiss-Prot | |
SH3 | UniProtKB/Swiss-Prot | |
ZF_BTK | UniProtKB/Swiss-Prot | |
SMART | BTK | UniProtKB/Swiss-Prot |
SH2 | UniProtKB/Swiss-Prot | |
SH3 | UniProtKB/Swiss-Prot | |
SM00233 | UniProtKB/Swiss-Prot | |
TyrKc | UniProtKB/Swiss-Prot | |
Superfamily-SCOP | SSF50044 | UniProtKB/Swiss-Prot |
SSF55550 | UniProtKB/Swiss-Prot | |
SSF56112 | UniProtKB/Swiss-Prot | |
UniGene | Hs.479670 | ENTREZGENE |
UniProt | D6RB05_HUMAN | UniProtKB/TrEMBL |
D6RB75_HUMAN | UniProtKB/TrEMBL | |
P42680 | ENTREZGENE | |
Q14219_HUMAN | UniProtKB/TrEMBL | |
TEC_HUMAN | UniProtKB/Swiss-Prot | |
UniProt Secondary | B7ZKZ6 | UniProtKB/Swiss-Prot |
Q3MIS5 | UniProtKB/Swiss-Prot |
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More on TEC | |
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Alliance Gene |
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NCBI Gene |
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Ensembl Gene |
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JBrowse: hg19 hg38 |
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HGNC Report |
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NCBI Genome Data Viewer |
CRRD Object Information | |
CRRD ID: | 732236 |
Created: | 2004-01-12 |
Species: | Homo sapiens |
Last Modified: | 2019-11-26 |
Status: | ACTIVE |
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.