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Gene: Rest (RE1-silencing transcription factor) Mus musculus
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Symbol: Rest
Name: RE1-silencing transcription factor
Description: Exhibits several functions, including DNA-binding transcription repressor activity, RNA polymerase II-specific; RNA polymerase II core promoter sequence-specific DNA binding activity; and protein homodimerization activity. Involved in several processes, including detection of mechanical stimulus involved in sensory perception of sound; generation of neurons; and regulation of gene expression. Localizes to the cytosol; nucleus; and transcriptional repressor complex. Predicted to colocalize with the histone methyltransferase complex. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 27; gingival fibromatosis 5; and nephroblastoma. Is expressed in several structures, including alimentary system; central nervous system; eye; genitourinary system; and peripheral nervous system ganglion. Orthologous to human REST (RE1 silencing transcription factor); PARTICIPATES IN Huntington's disease pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 5-fluorouracil; aflatoxin B1.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 2610008J04Rik; AA407358; MGC150099; neural-restrictive silencer factor; NRSF; REST/NRSF; REST4
Orthologs:
Homo sapiens (human) : REST (RE1 silencing transcription factor)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Rest (RE1-silencing transcription factor)  Alliance
Pan paniscus (bonobo/pygmy chimpanzee) : REST (RE1 silencing transcription factor)
Canis lupus familiaris (dog) : REST (RE1 silencing transcription factor)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Rest (RE1 silencing transcription factor)
Sus scrofa (pig) : REST (RE1 silencing transcription factor)
Chlorocebus sabaeus (African green monkey) : REST (RE1 silencing transcription factor)
Heterocephalus glaber (naked mole-rat) : Rest (RE1 silencing transcription factor)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm38 Ensembl577,265,491 - 77,286,432 (+)EnsemblGRCm38mm10GRCm38
GRCm38577,265,494 - 77,286,432 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv37577,694,519 - 77,712,722 (+)NCBIGRCm37mm9NCBIm37
MGSCv36578,342,716 - 78,357,759 (+)NCBImm8
Celera574,535,211 - 74,550,959 (+)NCBICelera
Cytogenetic Map5C3.3NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters

Additional Information

External Database Links
 
More on Rest
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 732239
Created: 2004-01-12
Species: Mus musculus
Last Modified: 2020-03-25
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.