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Gene: Shank3 (SH3 and multiple ankyrin repeat domains 3) Mus musculus
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Symbol: Shank3
Name: SH3 and multiple ankyrin repeat domains 3
Description: Exhibits ionotropic glutamate receptor binding activity; protein C-terminus binding activity; and scaffold protein binding activity. Involved in several processes, including modulation of chemical synaptic transmission; postsynapse organization; and regulation of synapse organization. Localizes to extrinsic component of cytoplasmic side of plasma membrane; glutamatergic synapse; and neuron spine. Predicted to colocalize with ionotropic glutamate receptor complex and postsynaptic membrane. Is expressed in brain and cerebral cortex. Used to study Phelan-McDermid syndrome; autism spectrum disorder; and schizophrenia. Human ortholog(s) of this gene implicated in Phelan-McDermid syndrome and schizophrenia 15. Orthologous to human SHANK3 (SH3 and multiple ankyrin repeat domains 3); PARTICIPATES IN glutamate signaling pathway; INTERACTS WITH 4,4'-sulfonyldiphenol; 4-hydroxyphenyl retinamide; bisphenol F.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: AI841104; proline-rich synapse-associated protein 2; proSAP2; SH3 and multiple ankyrin repeat domains protein 3; SH3 and multiple ankyrin repeat domains protein 3 variant c-3; SH3 and multiple ankyrin repeat domains protein 3 variant c-4; SH3 and multiple ankyrin repeat domains-like protein 3 variant 1; SH3 and multiple ankyrin repeat domains-like protein 3 variant 2; SH3 and multiple ankyrin repeat domains-like protein 3 variant 3; SH3 and multiple ankyrin repeat domains-like protein 3 variant c-1; SH3 and multiple ankyrin repeat domains-like protein 3 variant c-2; SH3 and multiple ankyrin repeat domains-like protein 3 variant d-1; SH3 and multiple ankyrin repeat domains-like protein 3 variant d-2; SH3 and multiple ankyrin repeat domains-like protein 3 variant d-3; SH3 and multiple ankyrin repeat domains-like protein 3 variant e-1; SH3 and multiple ankyrin repeat domains-like protein 3 variant e-2; SH3/ankyrin domain gene 3; shank3 splice variant II; shank3 splice variant III; shank3 splice variant IV; Shank3b; SHANK3c-3; SHANK3c-4; shank3e splice variant III; shank3e splice variant IV; SPANK-2
Orthologs:
Homo sapiens (human) : SHANK3 (SH3 and multiple ankyrin repeat domains 3)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Shank3 (SH3 and multiple ankyrin repeat domains 3)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Shank3 (SH3 and multiple ankyrin repeat domains 3)
Pan paniscus (bonobo/pygmy chimpanzee) : SHANK3 (SH3 and multiple ankyrin repeat domains 3)
Canis lupus familiaris (dog) : SHANK3 (SH3 and multiple ankyrin repeat domains 3)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Shank3 (SH3 and multiple ankyrin repeat domains 3)
Sus scrofa (pig) : SHANK3 (SH3 and multiple ankyrin repeat domains 3)
Chlorocebus sabaeus (African green monkey) : SHANK3 (SH3 and multiple ankyrin repeat domains 3)
Heterocephalus glaber (naked mole-rat) : Shank3 (SH3 and multiple ankyrin repeat domains 3)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm38.p6 Ensembl1589,499,623 - 89,560,261 (+)EnsemblGRCm38mm10GRCm38
GRCm381589,493,013 - 89,560,261 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv371589,330,288 - 89,390,692 (+)NCBIGRCm37mm9NCBIm37
MGSCv361589,327,624 - 89,386,090 (+)NCBImm8
Celera1591,629,363 - 91,689,694 (+)NCBICelera
Cytogenetic Map15E3NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
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References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
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Additional Information

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Nomenclature History
 
More on Shank3
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 732252
Created: 2004-01-12
Species: Mus musculus
Last Modified: 2020-07-28
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.