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Gene: FGFR1 (fibroblast growth factor receptor 1) Homo sapiens
Symbol: FGFR1
Name: fibroblast growth factor receptor 1
CRRD ID: 732290
Description: Exhibits several functions, including fibroblast growth factor binding activity; fibroblast growth factor-activated receptor activity; and heparin binding activity. Involved in several processes, including positive regulation of endothelial cell migration; positive regulation of intracellular signal transduction; and protein phosphorylation. Localizes to plasma membrane and receptor complex. Implicated in several diseases, including Jackson-Weiss syndrome; bone disease (multiple); cleft lip; hematologic cancer (multiple); and hypogonadotropic hypogonadism (multiple). Biomarker of several diseases, including acoustic neuroma; fatty liver disease; fibrolamellar carcinoma; obesity; and renal cell carcinoma.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: basic fibroblast growth factor receptor 1; bFGF-R-1; BFGFR; CD331; CEK; ECCL; FGFBR; FGFR-1; FGFR1/PLAG1 fusion; fibroblast growth factor receptor 1 (fms-related tyrosine kinase 2, Pfeiffer syndrome); FLG; FLJ99988; FLT-2; FLT2; FMS-like tyrosine kinase 2; fms-related tyrosine kinase 2; HBGFR; heparin-binding growth factor receptor; HH2; HRTFDS; hydroxyaryl-protein kinase; KAL2; Kallmann syndrome 2 (autosomal dominant); N-SAM; OGD; proto-oncogene c-Fgr; soluble FGFR1 variant 1; soluble FGFR1 variant 2
Mus musculus (house mouse) : Fgfr1 (fibroblast growth factor receptor 1)  MGI  Alliance
Rattus norvegicus (Norway rat) : Fgfr1 (Fibroblast growth factor receptor 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Fgfr1 (fibroblast growth factor receptor 1)
Pan paniscus (bonobo/pygmy chimpanzee) : FGFR1 (fibroblast growth factor receptor 1)
Canis lupus familiaris (dog) : FGFR1 (fibroblast growth factor receptor 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Fgfr1 (fibroblast growth factor receptor 1)
Sus scrofa (pig) : FGFR1 (fibroblast growth factor receptor 1)
Chlorocebus sabaeus (African green monkey) : FGFR1 (fibroblast growth factor receptor 1)
Heterocephalus glaber (naked mole-rat) : Fgfr1 (fibroblast growth factor receptor 1)
more info ...
Allele / Splice: See ClinVar data
Is Marker For: QTLs:   SCL6_H  
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38.p13 Ensembl838,400,215 - 38,468,834 (-)EnsemblGRCh38hg38GRCh38
GRCh38838,411,143 - 38,468,635 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37838,268,656 - 38,326,352 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36838,387,813 - 38,445,509 (-)NCBINCBI36hg18NCBI36
Build 34838,389,448 - 38,445,293NCBI
Celera837,221,633 - 37,279,334 (-)NCBI
Cytogenetic Map8p11.23NCBI
HuRef836,802,638 - 36,860,684 (-)NCBIHuRef
CHM1_1838,470,562 - 38,528,261 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Candidate Gene Status
Comparative Map Data
Position Markers