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Gene: Lox (lysyl oxidase) Mus musculus
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Symbol: Lox
Name: lysyl oxidase
Description: Exhibits protein-lysine 6-oxidase activity. Involved in several processes, including circulatory system development; collagen fibril organization; and regulation of signal transduction. Localizes to the collagen trimer and extracellular matrix. Used to study Menkes disease and Williams-Beuren syndrome. Human ortholog(s) of this gene implicated in Ehlers-Danlos syndrome; Menkes disease; hypertension; and thoracic aortic aneurysm. Is expressed in several structures, including alimentary system; genitourinary system; heart and pericardium; lung; and sensory organ. Orthologous to human LOX (lysyl oxidase).
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: AI893619; protein-lysine 6-oxidase; ras excision protein; ras recision; ras recision gene (rrg); rrg; TSC-160
Orthologs:
Homo sapiens (human) : LOX (lysyl oxidase)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Lox (lysyl oxidase)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Lox (lysyl oxidase)
Pan paniscus (bonobo/pygmy chimpanzee) : LOX (lysyl oxidase)
Canis lupus familiaris (dog) : LOX (lysyl oxidase)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Lox (lysyl oxidase)
Sus scrofa (pig) : LOX (lysyl oxidase)
Chlorocebus sabaeus (green monkey) : LOX (lysyl oxidase)
Heterocephalus glaber (naked mole-rat) : Lox (lysyl oxidase)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm38 Ensembl1852,516,067 - 52,529,867 (-)Ensembl
GRCm381852,516,060 - 52,529,867 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv371852,676,892 - 52,689,362 (-)NCBIGRCm37mm9NCBIm37
MGSCv361852,641,436 - 52,655,072 (-)NCBImm8
Celera1853,828,763 - 53,842,511 (-)NCBICelera
Cytogenetic Map18 D1NCBI
cM Map1828.22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters

Additional Information

External Database Links
 
More on Lox
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 732343
Created: 2004-01-12
Species: Mus musculus
Last Modified: 2020-02-04
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.