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Gene: Lox (lysyl oxidase) Mus musculus
Symbol: Lox
Name: lysyl oxidase
Description: Exhibits protein-lysine 6-oxidase activity. Involved in several processes, including circulatory system development; collagen fibril organization; and regulation of signal transduction. Localizes to the collagen trimer and extracellular matrix. Used to study Menkes disease and Williams-Beuren syndrome. Human ortholog(s) of this gene implicated in Ehlers-Danlos syndrome; Menkes disease; hypertension; and thoracic aortic aneurysm. Is expressed in several structures, including alimentary system; genitourinary system; heart and pericardium; lung; and sensory organ. Orthologous to human LOX (lysyl oxidase).
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: AI893619; protein-lysine 6-oxidase; ras excision protein; ras recision; ras recision gene (rrg); rrg; TSC-160
Homo sapiens (human) : LOX (lysyl oxidase)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Lox (lysyl oxidase)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Lox (lysyl oxidase)
Pan paniscus (bonobo/pygmy chimpanzee) : LOX (lysyl oxidase)
Canis lupus familiaris (dog) : LOX (lysyl oxidase)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Lox (lysyl oxidase)
Sus scrofa (pig) : LOX (lysyl oxidase)
Chlorocebus sabaeus (green monkey) : LOX (lysyl oxidase)
Heterocephalus glaber (naked mole-rat) : Lox (lysyl oxidase)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38 Ensembl1852,516,067 - 52,529,867 (-)Ensembl
GRCm381852,516,060 - 52,529,867 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv371852,676,892 - 52,689,362 (-)NCBIGRCm37mm9NCBIm37
MGSCv361852,641,436 - 52,655,072 (-)NCBImm8
Celera1853,828,763 - 53,842,511 (-)NCBICelera
Cytogenetic Map18 D1NCBI
cM Map1828.22NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Lox
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 732343
Created: 2004-01-12
Species: Mus musculus
Last Modified: 2020-02-04
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.