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Gene: BIN1 (bridging integrator 1) Homo sapiens
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Symbol: BIN1
Name: bridging integrator 1
Description: Exhibits several functions, including aspartic-type endopeptidase inhibitor activity; cytoskeletal protein binding activity; and enzyme binding activity. Involved in several processes, including T-tubule organization; negative regulation of amyloid precursor protein catabolic process; and regulation of neurogenesis. Localizes to several cellular components, including the axon; cytosol; and lipid tube. Colocalizes with the cytoskeleton. Implicated in breast carcinoma; centronuclear myopathy 2; and prostate adenocarcinoma.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: AMPH2; amphiphysin II; amphiphysin-like protein; AMPHL; box dependant MYC interacting protein 1; box-dependent myc-interacting protein 1; CNM2; DKFZp547F068; MGC10367; myc box dependent interacting protein 1; myc box-dependent-interacting protein 1; SH3P9
Orthologs:
Mus musculus (house mouse) : Bin1 (bridging integrator 1)  MGI  Alliance
Rattus norvegicus (Norway rat) : Bin1 (bridging integrator 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Bin1 (bridging integrator 1)
Pan paniscus (bonobo/pygmy chimpanzee) : BIN1 (bridging integrator 1)
Canis lupus familiaris (dog) : BIN1 (bridging integrator 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Bin1 (bridging integrator 1)
Sus scrofa (pig) : BIN1 (bridging integrator 1)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382127,048,023 - 127,107,154 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh372127,805,599 - 127,864,903 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362127,522,077 - 127,581,334 (-)NCBINCBI36hg18NCBI36
Build 342127,521,838 - 127,581,094NCBI
Celera2121,117,653 - 121,176,919 (-)NCBI
Cytogenetic Map2q14.3NCBI
HuRef2120,113,344 - 120,172,651 (-)NCBIHuRef
CHM1_12127,809,107 - 127,868,406 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
 
More on BIN1
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 732350
Created: 2004-01-12
Species: Homo sapiens
Last Modified: 2019-11-26
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.