Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   
Gene: BIN1 (bridging integrator 1) Homo sapiens
Symbol: BIN1
Name: bridging integrator 1
Description: Exhibits several functions, including aspartic-type endopeptidase inhibitor activity; cytoskeletal protein binding activity; and enzyme binding activity. Involved in several processes, including T-tubule organization; negative regulation of amyloid precursor protein catabolic process; and regulation of neurogenesis. Localizes to several cellular components, including the axon; cytosol; and lipid tube. Colocalizes with the cytoskeleton. Implicated in breast carcinoma; centronuclear myopathy 2; and prostate adenocarcinoma.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: AMPH2; amphiphysin II; amphiphysin-like protein; AMPHL; box dependant MYC interacting protein 1; box-dependent myc-interacting protein 1; CNM2; DKFZp547F068; MGC10367; myc box dependent interacting protein 1; myc box-dependent-interacting protein 1; SH3P9
Mus musculus (house mouse) : Bin1 (bridging integrator 1)  MGI  Alliance
Rattus norvegicus (Norway rat) : Bin1 (bridging integrator 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Bin1 (bridging integrator 1)
Pan paniscus (bonobo/pygmy chimpanzee) : BIN1 (bridging integrator 1)
Canis lupus familiaris (dog) : BIN1 (bridging integrator 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Bin1 (bridging integrator 1)
Sus scrofa (pig) : BIN1 (bridging integrator 1)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh382127,048,023 - 127,107,154 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh372127,805,599 - 127,864,903 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362127,522,077 - 127,581,334 (-)NCBINCBI36hg18NCBI36
Build 342127,521,838 - 127,581,094NCBI
Celera2121,117,653 - 121,176,919 (-)NCBI
Cytogenetic Map2q14.3NCBI
HuRef2120,113,344 - 120,172,651 (-)NCBIHuRef
CHM1_12127,809,107 - 127,868,406 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status



Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
More on BIN1
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 732350
Created: 2004-01-12
Species: Homo sapiens
Last Modified: 2019-11-26
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.