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Gene: POLA1 (DNA polymerase alpha 1, catalytic subunit) Homo sapiens
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Symbol: POLA1
Name: DNA polymerase alpha 1, catalytic subunit
Description: This gene encodes the catalytic subunit of DNA polymerase, which together with a regulatory and two primase subunits, forms the DNA polymerase alpha complex. The catalytic subunit plays an essential role in the initiation of DNA replication. [provided by RefSeq, Mar 2010]
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: DKFZp686K1672; DNA polymerase alpha 1 catalytic subunit; DNA polymerase alpha catalytic subunit; DNA polymerase alpha catalytic subunit p180; DNA polymerase alpha p180 subunit; dna polymerase alpha subunit i; N syndrome (mental retardation, malformations, chromosome breakage); NSX; p180; POLA; polymerase (DNA directed), alpha 1; polymerase (DNA directed), alpha 1, catalytic subunit; polymerase (DNA) alpha 1, catalytic subunit; polymerase (DNA-directed), alpha (70kD)
Orthologs:
Mus musculus (house mouse) : Pola1 (polymerase (DNA directed), alpha 1)  MGI  Alliance
Rattus norvegicus (Norway rat) : Pola1 (DNA polymerase alpha 1, catalytic subunit)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Pola1 (DNA polymerase alpha 1, catalytic subunit)
Pan paniscus (bonobo/pygmy chimpanzee) : POLA1 (DNA polymerase alpha 1, catalytic subunit)
Canis lupus familiaris (dog) : POLA1 (DNA polymerase alpha 1, catalytic subunit)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Pola1 (DNA polymerase alpha 1, catalytic subunit)
Sus scrofa (pig) : POLA1 (DNA polymerase alpha 1, catalytic subunit)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X24,693,833 - 24,996,986 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37X24,712,038 - 25,015,103 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36X24,621,977 - 24,925,024 (+)NCBINCBI36hg18NCBI36
Build 34X24,471,720 - 24,774,757NCBI
CeleraX28,834,936 - 29,139,042 (+)NCBI
Cytogenetic MapXp22.11-p21.3NCBI
HuRefX22,454,314 - 22,756,924 (+)NCBIHuRef
CHM1_1X24,743,660 - 25,046,638 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
Nomenclature History
 
More on POLA1
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 732365
Created: 2004-01-12
Species: Homo sapiens
Last Modified: 2019-08-06
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.