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Gene: Pola1 (polymerase (DNA directed), alpha 1) Mus musculus
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Symbol: Pola1
Name: polymerase (DNA directed), alpha 1
Description: Exhibits DNA-directed DNA polymerase activity and protein heterodimerization activity. Involved in DNA replication. Localizes to the alpha DNA polymerase:primase complex. Predicted to colocalize with the chromatin. Human ortholog(s) of this gene implicated in syndromic X-linked intellectual disability. Orthologous to human POLA1 (DNA polymerase alpha 1, catalytic subunit); PARTICIPATES IN DNA replication pathway; purine metabolic pathway; pyrimidine metabolic pathway; INTERACTS WITH 1,1-dichloroethene; 1-chloro-2,4-dinitrobenzene; 2,2',4,4',5,5'-hexachlorobiphenyl.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: AW321876; DNA polymerase alpha 1, 180 kDa; DNA polymerase alpha catalytic subunit; DNA polymerase alpha catalytic subunit p180; G7a/Bat6Hom; Pola; polymerase, alpha 1
Orthologs:
Homo sapiens (human) : POLA1 (DNA polymerase alpha 1, catalytic subunit)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Pola1 (DNA polymerase alpha 1, catalytic subunit)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Pola1 (DNA polymerase alpha 1, catalytic subunit)
Pan paniscus (bonobo/pygmy chimpanzee) : POLA1 (DNA polymerase alpha 1, catalytic subunit)
Canis lupus familiaris (dog) : POLA1 (DNA polymerase alpha 1, catalytic subunit)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Pola1 (DNA polymerase alpha 1, catalytic subunit)
Sus scrofa (pig) : POLA1 (DNA polymerase alpha 1, catalytic subunit)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm38X93,304,766 - 93,632,387 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv37X90,550,105 - 90,877,494 (-)NCBIGRCm37mm9NCBIm37
MGSCv36X89,557,486 - 89,884,874 (-)NCBImm8
CeleraX80,226,588 - 80,553,952 (-)NCBICelera
Cytogenetic MapX C3NCBI
cM MapX41.06NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters

Additional Information

External Database Links
 
More on Pola1
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 732366
Created: 2004-01-12
Species: Mus musculus
Last Modified: 2019-09-12
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.