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Gene: Pola1 (polymerase (DNA directed), alpha 1) Mus musculus
Symbol: Pola1
Name: polymerase (DNA directed), alpha 1
Description: Exhibits DNA-directed DNA polymerase activity and protein heterodimerization activity. Involved in DNA replication. Localizes to the alpha DNA polymerase:primase complex. Predicted to colocalize with the chromatin. Human ortholog(s) of this gene implicated in syndromic X-linked intellectual disability. Orthologous to human POLA1 (DNA polymerase alpha 1, catalytic subunit); PARTICIPATES IN DNA replication pathway; purine metabolic pathway; pyrimidine metabolic pathway; INTERACTS WITH 1,1-dichloroethene; 1-chloro-2,4-dinitrobenzene; 2,2',4,4',5,5'-hexachlorobiphenyl.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: AW321876; DNA polymerase alpha 1, 180 kDa; DNA polymerase alpha catalytic subunit; DNA polymerase alpha catalytic subunit p180; G7a/Bat6Hom; Pola; polymerase, alpha 1
Homo sapiens (human) : POLA1 (DNA polymerase alpha 1, catalytic subunit)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Pola1 (DNA polymerase alpha 1, catalytic subunit)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Pola1 (DNA polymerase alpha 1, catalytic subunit)
Pan paniscus (bonobo/pygmy chimpanzee) : POLA1 (DNA polymerase alpha 1, catalytic subunit)
Canis lupus familiaris (dog) : POLA1 (DNA polymerase alpha 1, catalytic subunit)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Pola1 (DNA polymerase alpha 1, catalytic subunit)
Sus scrofa (pig) : POLA1 (DNA polymerase alpha 1, catalytic subunit)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38X93,304,766 - 93,632,387 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv37X90,550,105 - 90,877,494 (-)NCBIGRCm37mm9NCBIm37
MGSCv36X89,557,486 - 89,884,874 (-)NCBImm8
CeleraX80,226,588 - 80,553,952 (-)NCBICelera
Cytogenetic MapX C3NCBI
cM MapX41.06NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Pola1
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 732366
Created: 2004-01-12
Species: Mus musculus
Last Modified: 2019-09-12
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.