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Gene: CARD9 (caspase recruitment domain family member 9) Homo sapiens
Symbol: CARD9
Name: caspase recruitment domain family member 9
Description: Exhibits CARD domain binding activity and protein homodimerization activity. Involved in positive regulation of I-kappaB kinase/NF-kappaB signaling; positive regulation of JNK cascade; and positive regulation of cysteine-type endopeptidase activity involved in apoptotic process. Localizes to the cytoplasm and protein-containing complex. Implicated in chronic mucocutaneous candidiasis.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: CANDF2; caspase recruitment domain family, member 9; caspase recruitment domain protein 9; caspase recruitment domain-containing protein 9; hCARD9
Mus musculus (house mouse) : Card9 (caspase recruitment domain family, member 9)  MGI  Alliance
Rattus norvegicus (Norway rat) : Card9 (caspase recruitment domain family, member 9)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Card9 (caspase recruitment domain family member 9)
Pan paniscus (bonobo/pygmy chimpanzee) : CARD9 (caspase recruitment domain family member 9)
Canis lupus familiaris (dog) : CARD9 (caspase recruitment domain family member 9)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Card9 (caspase recruitment domain family member 9)
Sus scrofa (pig) : CARD9 (caspase recruitment domain family member 9)
Chlorocebus sabaeus (green monkey) : CARD9 (caspase recruitment domain family member 9)
Heterocephalus glaber (naked mole-rat) : Card9 (caspase recruitment domain family member 9)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38 Ensembl9136,361,903 - 136,373,681 (-)Ensembl
GRCh389136,363,956 - 136,373,669 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh379139,258,408 - 139,268,133 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 369138,378,229 - 138,387,939 (-)NCBINCBI36hg18NCBI36
Build 349136,534,245 - 136,543,945NCBI
Celera9109,773,344 - 109,783,069 (-)NCBI
Cytogenetic Map9q34.3NCBI
HuRef9108,717,764 - 108,727,489 (-)NCBIHuRef
CHM1_19139,406,604 - 139,416,329 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on CARD9
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 732385
Created: 2004-01-12
Species: Homo sapiens
Last Modified: 2020-02-11
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.