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Gene: MYH9 (myosin heavy chain 9) Homo sapiens
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Symbol: MYH9
Name: myosin heavy chain 9
CRRD ID: 732401
Description: Exhibits several functions, including adenyl ribonucleotide binding activity; nucleoside-triphosphatase activity; and protein homodimerization activity. Involved in several processes, including actin cytoskeleton organization; myeloid cell differentiation; and negative regulation of actin filament severing. Localizes to several cellular components, including actin cytoskeleton; myosin II filament; and ruffle. Colocalizes with COP9 signalosome and immunological synapse. Implicated in several diseases, including auditory system disease (multiple); autosomal dominant Alport syndrome; blood platelet disease (multiple); end stage renal disease; and proteinuria. Biomarker of MYH-9 related disease.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: BDPLT6; cellular myosin heavy chain, type A; DFNA17; EPSTS; FTNS; MATINS; MGC104539; MHA; MYH9 variant protein; myosin heavy chain, non-muscle IIa; myosin, heavy chain 9, non-muscle; myosin, heavy polypeptide 9; myosin-9; NMHC-II-A; NMMHC II-a; NMMHC-A; NMMHC-IIA; NMMHCA; non-muscle myosin heavy chain 9; non-muscle myosin heavy chain A; non-muscle myosin heavy chain IIa; non-muscle myosin heavy polypeptide 9; nonmuscle myosin heavy chain II-A
Orthologs:
Mus musculus (house mouse) : Myh9 (myosin, heavy polypeptide 9, non-muscle)  MGI  Alliance
Rattus norvegicus (Norway rat) : Myh9 (myosin, heavy chain 9)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Myh9 (myosin heavy chain 9)
Pan paniscus (bonobo/pygmy chimpanzee) : MYH9 (myosin heavy chain 9)
Canis lupus familiaris (dog) : MYH9 (myosin heavy chain 9)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Myh9 (myosin heavy chain 9)
Sus scrofa (pig) : MYH9 (myosin heavy chain 9)
Chlorocebus sabaeus (African green monkey) : MYH9 (myosin heavy chain 9)
Heterocephalus glaber (naked mole-rat) : Myh9 (myosin heavy chain 9)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl2236,281,277 - 36,388,067 (-)EnsemblGRCh38hg38GRCh38
GRCh38.p13 Ensembl2236,281,280 - 36,387,967 (-)EnsemblGRCh38hg38GRCh38
GRCh382236,281,280 - 36,387,967 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh372236,677,323 - 36,784,107 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362235,007,272 - 35,113,927 (-)NCBINCBI36hg18NCBI36
Build 342235,001,826 - 35,108,481NCBI
Celera2220,479,895 - 20,586,681 (-)NCBI
Cytogenetic Map22q12.3NCBI
HuRef2219,645,404 - 19,752,216 (-)NCBIHuRef
CHM1_12236,636,447 - 36,743,245 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
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