Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   
Gene: MYH9 (myosin heavy chain 9) Homo sapiens
Analyze
Symbol: MYH9
Name: myosin heavy chain 9
Description: Exhibits several functions, including adenyl ribonucleotide binding activity; nucleoside-triphosphatase activity; and protein homodimerization activity. Involved in several processes, including actin cytoskeleton organization; myeloid cell differentiation; and negative regulation of actin filament severing. Localizes to several cellular components, including the actin cytoskeleton; myosin II filament; and ruffle. Colocalizes with the COP9 signalosome and immunological synapse. Implicated in several diseases, including auditory system disease (multiple); autosomal dominant Alport syndrome; blood platelet disease (multiple); end stage renal failure; and proteinuria. Biomarker of MYH-9 related disease.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: BDPLT6; cellular myosin heavy chain, type A; DFNA17; EPSTS; FTNS; MATINS; MGC104539; MHA; MYH9 variant protein; myosin heavy chain, non-muscle IIa; myosin, heavy chain 9, non-muscle; myosin, heavy polypeptide 9; myosin-9; NMHC-II-A; NMMHC II-a; NMMHC-A; NMMHC-IIA; NMMHCA; non-muscle myosin heavy chain 9; non-muscle myosin heavy chain A; non-muscle myosin heavy chain IIa; non-muscle myosin heavy polypeptide 9; nonmuscle myosin heavy chain II-A
Orthologs:
Mus musculus (house mouse) : Myh9 (myosin, heavy polypeptide 9, non-muscle)  MGI  Alliance
Rattus norvegicus (Norway rat) : Myh9 (myosin, heavy chain 9)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Myh9 (myosin heavy chain 9)
Pan paniscus (bonobo/pygmy chimpanzee) : MYH9 (myosin heavy chain 9)
Canis lupus familiaris (dog) : MYH9 (myosin heavy chain 9)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Myh9 (myosin heavy chain 9)
Sus scrofa (pig) : MYH9 (myosin heavy chain 9)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382236,281,277 - 36,388,067 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh372236,677,323 - 36,784,107 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362235,007,272 - 35,113,927 (-)NCBINCBI36hg18NCBI36
Build 342235,001,826 - 35,108,481NCBI
Celera2220,479,895 - 20,586,681 (-)NCBI
Cytogenetic Map22q12.3NCBI
HuRef2219,645,404 - 19,752,216 (-)NCBIHuRef
CHM1_12236,636,447 - 36,743,245 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
Nomenclature History
 
More on MYH9
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 732401
Created: 2004-01-12
Species: Homo sapiens
Last Modified: 2019-11-26
Status: ACTIVE



NHLBI Logo

RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.