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Gene: AKT2 (AKT serine/threonine kinase 2) Homo sapiens
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Symbol: AKT2
Name: AKT serine/threonine kinase 2
Description: Exhibits ATP binding activity and protein serine/threonine kinase activity. Involved in several processes, including positive regulation of mitochondrial membrane potential; positive regulation of small molecule metabolic process; and regulation of transmembrane transport. Localizes to the cytosol; nucleoplasm; and protein-containing complex. Implicated in glucose metabolism disease (multiple) and reproductive organ cancer (multiple). Biomarker of astrocytoma; colorectal cancer; malignant glioma; obesity; and type 2 diabetes mellitus.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: HIHGHH; Murine thymoma viral (v-akt) homolog-2; murine thymoma viral (v-akt) oncogene homolog 2; PKB beta; PKBB; PKBBETA; PRKBB; protein kinase Akt-2; protein kinase B beta; putative v-akt murine thymoma viral oncoprotein 2; rac protein kinase beta; RAC-BETA; RAC-beta serine/threonine-protein kinase; RAC-PK-beta; v-akt murine thymoma viral oncogene homolog 2
Orthologs:
Mus musculus (house mouse) : Akt2 (thymoma viral proto-oncogene 2)  MGI  Alliance
Rattus norvegicus (Norway rat) : Akt2 (AKT serine/threonine kinase 2)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Akt2 (AKT serine/threonine kinase 2)
Pan paniscus (bonobo/pygmy chimpanzee) : AKT2 (AKT serine/threonine kinase 2)
Canis lupus familiaris (dog) : AKT2 (AKT serine/threonine kinase 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Akt2 (AKT serine/threonine kinase 2)
Sus scrofa (pig) : AKT2 (AKT serine/threonine kinase 2)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381940,230,317 - 40,285,531 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371940,736,224 - 40,791,443 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361945,428,064 - 45,483,105 (-)NCBINCBI36hg18NCBI36
Build 341945,431,555 - 45,483,034NCBI
Celera1937,535,771 - 37,590,707 (-)NCBI
Cytogenetic Map19q13.2NCBI
HuRef1937,171,156 - 37,226,119 (-)NCBIHuRef
CHM1_11940,735,896 - 40,790,984 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
Nomenclature History
 
More on AKT2
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 732407
Created: 2004-01-12
Species: Homo sapiens
Last Modified: 2019-11-05
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.