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Gene: AKT2 (AKT serine/threonine kinase 2) Homo sapiens
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Symbol: AKT2
Name: AKT serine/threonine kinase 2
CRRD ID: 732407
Description: Exhibits ATP binding activity and protein serine/threonine kinase activity. Involved in several processes, including positive regulation of mitochondrial membrane potential; positive regulation of small molecule metabolic process; and regulation of transmembrane transport. Localizes to cytosol; nucleoplasm; and protein-containing complex. Implicated in glucose metabolism disease (multiple) and reproductive organ cancer (multiple). Biomarker of astrocytoma; colorectal cancer; malignant glioma; obesity; and type 2 diabetes mellitus.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: HIHGHH; Murine thymoma viral (v-akt) homolog-2; murine thymoma viral (v-akt) oncogene homolog 2; PKB beta; PKBB; PKBBETA; PRKBB; protein kinase Akt-2; protein kinase B beta; putative v-akt murine thymoma viral oncoprotein 2; rac protein kinase beta; RAC-BETA; RAC-beta serine/threonine-protein kinase; RAC-PK-beta; v-akt murine thymoma viral oncogene homolog 2
Orthologs:
Mus musculus (house mouse) : Akt2 (thymoma viral proto-oncogene 2)  MGI  Alliance
Rattus norvegicus (Norway rat) : Akt2 (AKT serine/threonine kinase 2)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Akt2 (AKT serine/threonine kinase 2)
Pan paniscus (bonobo/pygmy chimpanzee) : AKT2 (AKT serine/threonine kinase 2)
Canis lupus familiaris (dog) : AKT2 (AKT serine/threonine kinase 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Akt2 (AKT serine/threonine kinase 2)
Sus scrofa (pig) : AKT2 (AKT serine/threonine kinase 2)
Chlorocebus sabaeus (African green monkey) : AKT2 (AKT serine/threonine kinase 2)
Heterocephalus glaber (naked mole-rat) : Akt2 (AKT serine/threonine kinase 2)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1940,230,317 - 40,285,536 (-)EnsemblGRCh38hg38GRCh38
GRCh381940,230,317 - 40,285,531 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371940,736,224 - 40,791,443 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361945,428,064 - 45,483,105 (-)NCBINCBI36hg18NCBI36
Build 341945,431,555 - 45,483,034NCBI
Celera1937,535,771 - 37,590,707 (-)NCBI
Cytogenetic Map19q13.2NCBI
HuRef1937,171,156 - 37,226,119 (-)NCBIHuRef
CHM1_11940,735,896 - 40,790,984 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
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Molecular Pathway Annotations
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References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
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Clinical Variants

Additional Information

External Database Links
Nomenclature History
 
More on AKT2
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 732407
Created: 2004-01-12
Species: Homo sapiens
Last Modified: 2020-11-10
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.