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Gene: RBBP7 (RB binding protein 7, chromatin remodeling factor) Homo sapiens
Symbol: RBBP7
Name: RB binding protein 7, chromatin remodeling factor
Description: This protein is a ubiquitously expressed nuclear protein and belongs to a highly conserved subfamily of WD-repeat proteins. It is found among several proteins that binds directly to retinoblastoma protein, which regulates cell proliferation. The encoded protein is found in many histone deacetylase complexes, including mSin3 co-repressor complex. It is also present in protein complexes involved in chromatin assembly. This protein can interact with BRCA1 tumor-suppressor gene and may have a role in the regulation of cell proliferation and differentiation. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2010]
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: G1/S transition control protein-binding protein RbAp46; histone acetyltransferase type B subunit 2; histone-binding protein RBBP7; MGC138867; MGC138868; nucleosome-remodeling factor subunit RBAP46; RbAp46; RBBP-7; retinoblastoma binding protein 7; retinoblastoma-binding protein 7; retinoblastoma-binding protein p46; retinoblastoma-binding protein RbAp46
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38X16,844,650 - 16,870,411 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37X16,862,773 - 16,888,565 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36X16,772,698 - 16,798,386 (-)NCBINCBI36hg18NCBI36
Build 34X16,622,433 - 16,648,114NCBI
CeleraX20,981,704 - 21,007,178 (-)NCBI
Cytogenetic MapXp22.2NCBI
HuRefX14,623,294 - 14,649,232 (-)NCBIHuRef
CHM1_1X16,893,198 - 16,918,914 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on RBBP7
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 732412
Created: 2004-01-12
Species: Homo sapiens
Last Modified: 2019-08-06
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.