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Gene: TXN (thioredoxin) Homo sapiens
Symbol: TXN
Name: thioredoxin
Description: Exhibits RNA binding activity. Involved in several processes, including negative regulation of hydrogen peroxide-induced cell death; positive regulation of DNA binding activity; and positive regulation of peptidyl-serine phosphorylation. Localizes to the cytosol and nucleoplasm. Biomarker of dilated cardiomyopathy; intermediate coronary syndrome; myocardial infarction; and myocarditis.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: ADF; ATL-derived factor; DKFZp686B1993; MGC61975; SASP; surface-associated sulphydryl protein; testicular tissue protein Li 199; thioredoxin delta 3; TRDX; TRX; TRX1; TXN delta 3
Mus musculus (house mouse) : Txn1 (thioredoxin 1)  MGI  Alliance
Rattus norvegicus (Norway rat) : Txn1 (thioredoxin 1)  Alliance
Pan paniscus (bonobo/pygmy chimpanzee) : TXN (thioredoxin)
Canis lupus familiaris (dog) : LOC100687127 (thioredoxin-like)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Txn (thioredoxin)
Sus scrofa (pig) : TXN (thioredoxin)
more info ...
Related Pseudogenes: TXNP1   TXNP2   TXNP3   TXNP4   TXNP5   TXNP6   TXNP7  
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh389110,243,810 - 110,256,507 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh379113,006,092 - 113,018,920 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 369112,046,131 - 112,058,599 (-)NCBINCBI36hg18NCBI36
Build 349110,085,864 - 110,098,333NCBI
Celera983,507,936 - 83,520,398 (-)NCBI
Cytogenetic Map9q31.3NCBI
HuRef982,607,811 - 82,620,710 (-)NCBIHuRef
CHM1_19113,152,543 - 113,165,343 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status



Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
More on TXN
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 732441
Created: 2004-01-12
Species: Homo sapiens
Last Modified: 2019-11-26
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.