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Gene: CAPN10 (calpain 10) Homo sapiens
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Symbol: CAPN10
Name: calpain 10
Description: Exhibits calcium-dependent cysteine-type endopeptidase activity. Involved in several processes, including cellular response to insulin stimulus; positive regulation of transport; and type B pancreatic cell apoptotic process. Localizes to the cytosol and mitochondrion. Implicated in obesity; pancreatic cancer; polycystic ovary syndrome; and type 2 diabetes mellitus. Biomarker of type 2 diabetes mellitus.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: calcium-activated neutral protease; calcium-activated neutral proteinase 10; calpain-10; calpain-like protease CAPN10; CANP 10; CANP10; NIDDM1; non-insulin-dependent diabetes mellitus (common, type 2) 1
Orthologs:
Mus musculus (house mouse) : Capn10 (calpain 10)  MGI  Alliance
Rattus norvegicus (Norway rat) : Capn10 (calpain 10)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Capn10 (calpain 10)
Pan paniscus (bonobo/pygmy chimpanzee) : CAPN10 (calpain 10)
Canis lupus familiaris (dog) : CAPN10 (calpain 10)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Capn10 (calpain 10)
Sus scrofa (pig) : CAPN10 (calpain 10)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382240,586,734 - 240,599,104 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh372241,526,133 - 241,538,526 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362241,174,818 - 241,205,795 (+)NCBINCBI36hg18NCBI36
Build 342241,246,141 - 241,277,112NCBI
Celera2235,198,477 - 235,210,856 (+)NCBI
Cytogenetic Map2q37.3NCBI
HuRef2233,282,748 - 233,295,178 (+)NCBIHuRef
CHM1_12241,532,185 - 241,544,581 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated

Genomics

Candidate Gene Status
Comparative Map Data
Position Markers
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
Nomenclature History
 
More on CAPN10
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 732443
Created: 2004-01-12
Species: Homo sapiens
Last Modified: 2019-11-26
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.