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Gene: PLA2G6 (phospholipase A2 group VI) Homo sapiens
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Symbol: PLA2G6
Name: phospholipase A2 group VI
CRRD ID: 732454
Description: Exhibits identical protein binding activity; palmitoyl-CoA hydrolase activity; and phospholipase activity. Involved in antibacterial humoral response and glycerophospholipid metabolic process. Localizes to centriolar satellite; cytosol; and extracellular space. Implicated in dystonia 12; neuroaxonal dystrophy; and neurodegenerative disease (multiple). Biomarker of Duchenne muscular dystrophy.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: 2-lysophosphatidylcholine acylhydrolase; 85 kDa calcium-independent phospholipase A2; 85/88 kDa calcium-independent phospholipase A2; CaI-PLA2; calcium-independent phospholipase A2; cytosolic, calcium-independent phospholipase A2; group VI phospholipase A2; GVI; GVI PLA2; INAD1; intracellular membrane-associated calcium-independent phospholipase A2 beta; iPLA2; iPLA2-beta; IPLA2-VIA; iPLA2beta; NBIA2; NBIA2A; NBIA2B; neurodegeneration with brain iron accumulation 2; palmitoyl-CoA hydrolase; PARK14; patatin-like phospholipase domain containing 9; patatin-like phospholipase domain-containing protein 9; phospholipase a2, group vi; phospholipase A2, group VI (cytosolic, calcium-independent); PLA2; PNPLA9
Orthologs:
Mus musculus (house mouse) : Pla2g6 (phospholipase A2, group VI)  MGI  Alliance
Rattus norvegicus (Norway rat) : Pla2g6 (phospholipase A2 group VI)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Pla2g6 (phospholipase A2 group VI)
Pan paniscus (bonobo/pygmy chimpanzee) : PLA2G6 (phospholipase A2 group VI)
Canis lupus familiaris (dog) : PLA2G6 (phospholipase A2 group VI)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Pla2g6 (phospholipase A2 group VI)
Sus scrofa (pig) : PLA2G6 (phospholipase A2 group VI)
Chlorocebus sabaeus (African green monkey) : PLA2G6 (phospholipase A2 group VI)
Heterocephalus glaber (naked mole-rat) : Pla2g6 (phospholipase A2 group VI)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl2238,111,495 - 38,214,778 (-)EnsemblGRCh38hg38GRCh38
GRCh382238,111,495 - 38,181,830 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh372238,507,502 - 38,577,857 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362236,837,448 - 36,907,707 (-)NCBINCBI36hg18NCBI36
Build 342236,832,002 - 36,902,261NCBI
Celera2222,312,199 - 22,382,453 (-)NCBI
Cytogenetic Map22q13.1NCBI
HuRef2221,473,858 - 21,543,900 (-)NCBIHuRef
CHM1_12238,466,463 - 38,536,813 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
Nomenclature History
 
More on PLA2G6
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 732454
Created: 2004-01-12
Species: Homo sapiens
Last Modified: 2020-11-10
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.