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Gene: Pla2g6 (phospholipase A2, group VI) Mus musculus
Symbol: Pla2g6
Name: phospholipase A2, group VI
Description: Exhibits serine hydrolase activity. Predicted to be involved in several processes, including positive regulation of nitrogen compound metabolic process; positive regulation of secretion; and positive regulation of signal transduction. Predicted to localize to several cellular components, including the centriolar satellite; extracellular space; and mitochondrion. Used to study neurodegeneration with brain iron accumulation 2a. Human ortholog(s) of this gene implicated in dystonia 12; neuroaxonal dystrophy; and neurodegenerative disease (multiple). Is expressed in 1st branchial arch maxillary component; olfactory placode; otic pit; and trunk somite. Orthologous to human PLA2G6 (phospholipase A2 group VI); PARTICIPATES IN arachidonic acid metabolic pathway; glutamate signaling pathway; glycerophospholipid metabolic pathway; INTERACTS WITH 1,2-dichloroethane; 2,2',4,4',5,5'-hexachlorobiphenyl; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 85 kDa calcium-independent phospholipase A2; 85/88 kDa calcium-independent phospholipase A2; BB112799; caI-PLA2; group VI phospholipase A2; GVI PLA2; intracellular membrane-associated calcium-independent phospholipase A2 beta; iPLA(2)beta; iPLA2; iPLA2-beta; iPLA2beta; patatin-like phospholipase domain-containing protein 9; PNPLA9
Homo sapiens (human) : PLA2G6 (phospholipase A2 group VI)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Pla2g6 (phospholipase A2 group VI)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Pla2g6 (phospholipase A2 group VI)
Pan paniscus (bonobo/pygmy chimpanzee) : PLA2G6 (phospholipase A2 group VI)
Canis lupus familiaris (dog) : PLA2G6 (phospholipase A2 group VI)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Pla2g6 (phospholipase A2 group VI)
Sus scrofa (pig) : PLA2G6 (phospholipase A2 group VI)
Chlorocebus sabaeus (African green monkey) : PLA2G6 (phospholipase A2 group VI)
Heterocephalus glaber (naked mole-rat) : Pla2g6 (phospholipase A2 group VI)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38 Ensembl1579,286,228 - 79,328,390 (-)EnsemblGRCm38mm10GRCm38
GRCm381579,286,228 - 79,328,385 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv371579,116,658 - 79,158,598 (-)NCBIGRCm37mm9NCBIm37
MGSCv361579,113,483 - 79,155,423 (-)NCBImm8
Celera1581,406,243 - 81,447,891 (-)NCBICelera
Cytogenetic Map15E1NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Pla2g6
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 732455
Created: 2004-01-12
Species: Mus musculus
Last Modified: 2020-03-25
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.