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Gene: RNF40 (ring finger protein 40) Homo sapiens
Symbol: RNF40
Name: ring finger protein 40
Description: Exhibits mRNA 3'-UTR binding activity; protein homodimerization activity; and ubiquitin protein ligase binding activity. Contributes to ubiquitin-protein transferase activity. Involved in histone ubiquitination; negative regulation of mRNA polyadenylation; and positive regulation of histone H2B ubiquitination. Localizes to the HULC complex and nucleoplasm.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: 95 kDa retinoblastoma protein binding protein; 95 kDa retinoblastoma-associated protein; BRE1 E3 ubiquitin ligase homolog B; BRE1-B; BRE1B; DKFZp686K191; E3 ubiquitin-protein ligase BRE1B; KIAA0661; MGC13051; Rb-associated protein; RBP95; ring finger protein 40, E3 ubiquitin protein ligase; RING-type E3 ubiquitin transferase BRE1B; STARING
Mus musculus (house mouse) : Rnf40 (ring finger protein 40)  MGI  Alliance
Rattus norvegicus (Norway rat) : Rnf40 (ring finger protein 40)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Rnf40 (ring finger protein 40)
Pan paniscus (bonobo/pygmy chimpanzee) : RNF40 (ring finger protein 40)
Canis lupus familiaris (dog) : RNF40 (ring finger protein 40)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Rnf40 (ring finger protein 40)
Sus scrofa (pig) : RNF40 (ring finger protein 40)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh381630,761,612 - 30,800,231 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371630,772,933 - 30,787,628 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361630,681,131 - 30,694,040 (+)NCBINCBI36hg18NCBI36
Build 341630,681,130 - 30,694,037NCBI
Celera1629,510,882 - 29,523,813 (-)NCBI
Cytogenetic Map16p11.2NCBI
HuRef1628,335,742 - 28,350,458 (+)NCBIHuRef
CHM1_11632,090,075 - 32,104,789 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status



Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on RNF40
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 732458
Created: 2004-01-12
Species: Homo sapiens
Last Modified: 2019-11-26
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.