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Gene: POU3F4 (POU class 3 homeobox 4) Homo sapiens
Symbol: POU3F4
Name: POU class 3 homeobox 4
Description: This gene encodes a member of the POU-III class of neural transcription factors. This family member plays a role in inner ear development. The protein is thought to be involved in the mediation of epigenetic signals which induce striatal neuron-precursor differentiation. Mutations in this gene are associated with X chromosome-linked nonsyndromic mixed deafness. [provided by RefSeq, Dec 2012]
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: BRAIN-4; brain-specific homeobox/POU domain protein 4; BRN-4; BRN4; DFN3; DFNX2; OCT-9; octamer-binding protein 9; octamer-binding transcription factor 9; OTF-9; OTF9; POU domain, class 3, transcription factor 4
Mus musculus (house mouse) : Pou3f4 (POU domain, class 3, transcription factor 4)  MGI  Alliance
Rattus norvegicus (Norway rat) : Pou3f4 (POU class 3 homeobox 4)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Pou3f4 (POU class 3 homeobox 4)
Pan paniscus (bonobo/pygmy chimpanzee) : POU3F4 (POU class 3 homeobox 4)
Canis lupus familiaris (dog) : POU3F4 (POU class 3 homeobox 4)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Pou3f4 (POU class 3 homeobox 4)
Sus scrofa (pig) : POU3F4 (POU class 3 homeobox 4)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38X83,508,261 - 83,509,767 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37X82,763,269 - 82,764,775 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36X82,649,941 - 82,651,431 (+)NCBINCBI36hg18NCBI36
Build 34X82,569,445 - 82,570,920NCBI
CeleraX83,000,650 - 83,002,156 (+)NCBI
Cytogenetic MapXq21.1NCBI
HuRefX76,337,125 - 76,338,589 (+)NCBIHuRef
CHM1_1X82,657,165 - 82,658,671 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
More on POU3F4
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 732459
Created: 2004-01-12
Species: Homo sapiens
Last Modified: 2019-07-09
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.