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Gene: HCK (HCK proto-oncogene, Src family tyrosine kinase) Homo sapiens
Symbol: HCK
Name: HCK proto-oncogene, Src family tyrosine kinase
Description: Exhibits phosphotyrosine residue binding activity and protein tyrosine kinase activity. Involved in several processes, including protein phosphorylation; regulation of DNA-binding transcription factor activity; and regulation of organelle organization. Localizes to several cellular components, including the caveola; extrinsic component of cytoplasmic side of plasma membrane; and focal adhesion. Colocalizes with the actin filament.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: hematopoietic cell kinase; hemopoietic cell kinase; JTK9; p59-HCK/p60-HCK; p59Hck; p61Hck; tyrosine-protein kinase HCK
Mus musculus (house mouse) : Hck (hemopoietic cell kinase)  MGI  Alliance
Rattus norvegicus (Norway rat) : Hck (HCK proto-oncogene, Src family tyrosine kinase)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Hck (HCK proto-oncogene, Src family tyrosine kinase)
Pan paniscus (bonobo/pygmy chimpanzee) : HCK (HCK proto-oncogene, Src family tyrosine kinase)
Canis lupus familiaris (dog) : HCK (HCK proto-oncogene, Src family tyrosine kinase)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Hck (HCK proto-oncogene, Src family tyrosine kinase)
Sus scrofa (pig) : HCK (HCK proto-oncogene, Src family tyrosine kinase)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh382032,052,242 - 32,101,843 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh372030,639,991 - 30,689,659 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362030,103,718 - 30,153,320 (+)NCBINCBI36hg18NCBI36
Build 342030,103,717 - 30,153,316NCBI
Celera2027,396,349 - 27,446,028 (+)NCBI
Cytogenetic Map20q11.21NCBI
HuRef2027,428,653 - 27,478,333 (+)NCBIHuRef
CHM1_12030,543,895 - 30,593,543 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status



Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on HCK
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 732471
Created: 2004-01-12
Species: Homo sapiens
Last Modified: 2019-11-26
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.