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Gene: Grb2 (growth factor receptor bound protein 2) Mus musculus
Symbol: Grb2
Name: growth factor receptor bound protein 2
Description: Exhibits several functions, including ephrin receptor binding activity; protein phosphatase binding activity; and protein-macromolecule adaptor activity. Involved in several processes, including branching involved in labyrinthine layer morphogenesis; fibroblast growth factor receptor signaling pathway; and positive regulation of actin filament polymerization. Localizes to several cellular components, including COP9 signalosome; cell-cell junction; and vesicle membrane. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; hemolymphoid system gland; and lung. Human ortholog(s) of this gene implicated in breast cancer; prostate adenocarcinoma; and prostate cancer. Orthologous to human GRB2 (growth factor receptor bound protein 2).
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: AA408164; adapter protein GRB2; Ash; growth factor receptor-bound protein 2; SH2/SH3 adapter GRB2
Homo sapiens (human) : GRB2 (growth factor receptor bound protein 2)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Grb2 (growth factor receptor bound protein 2)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Grb2 (growth factor receptor bound protein 2)
Pan paniscus (bonobo/pygmy chimpanzee) : GRB2 (growth factor receptor bound protein 2)
Canis lupus familiaris (dog) : GRB2 (growth factor receptor bound protein 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Grb2 (growth factor receptor bound protein 2)
Sus scrofa (pig) : GRB2 (growth factor receptor bound protein 2)
Chlorocebus sabaeus (African green monkey) : GRB2 (growth factor receptor bound protein 2)
Heterocephalus glaber (naked mole-rat) : Grb2 (growth factor receptor bound protein 2)
more info ...
Related Pseudogenes: Gm12791   Grb2-ps1  
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38 Ensembl11115,644,045 - 115,708,597 (-)EnsemblGRCm38mm10GRCm38
GRCm3811115,644,045 - 115,708,597 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv3711115,505,444 - 115,569,911 (-)NCBIGRCm37mm9NCBIm37
MGSCv3611115,460,220 - 115,524,687 (-)NCBImm8
Celera11127,412,389 - 127,476,946 (-)NCBICelera
Cytogenetic Map11E2NCBI
cM Map1180.91NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Grb2
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 732474
Created: 2004-01-12
Species: Mus musculus
Last Modified: 2020-07-07
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.