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Gene: TGM2 (transglutaminase 2) Homo sapiens
Symbol: TGM2
Name: transglutaminase 2
Description: Exhibits protein-glutamine gamma-glutamyltransferase activity. Involved in several processes, including apoptotic cell clearance; cellular calcium ion homeostasis; and peptide cross-linking. Localizes to the cytosol; intrinsic component of plasma membrane; and mitochondrion.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: C polypeptide; C polypeptide, protein-glutamine-gamma-glutamyltransferase; epididymis secretory protein Li 45; G-ALPHA-h; GNAH; HEL-S-45; protein-glutamine gamma-glutamyltransferase 2; protein-glutamine-gamma-glutamyltransferase; TG(C); TG2; TGase C; TGase H; TGase-2; TGase-H; TGC; tissue transglutaminase; tissue-type transglutaminase; transglutaminase C; transglutaminase H; transglutaminase-2
Mus musculus (house mouse) : Tgm2 (transglutaminase 2, C polypeptide)  MGI  Alliance
Rattus norvegicus (Norway rat) : Tgm2 (transglutaminase 2)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Tgm2 (transglutaminase 2)
Pan paniscus (bonobo/pygmy chimpanzee) : TGM2 (transglutaminase 2)
Canis lupus familiaris (dog) : TGM2 (transglutaminase 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Tgm2 (transglutaminase 2)
Sus scrofa (pig) : TGM2 (transglutaminase 2)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh382038,127,385 - 38,166,508 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh372036,756,863 - 36,794,910 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362036,190,277 - 36,227,114 (-)NCBINCBI36hg18NCBI36
Build 342036,199,764 - 36,227,114NCBI
Celera2033,465,637 - 33,502,475 (-)NCBI
Cytogenetic Map20q11.23NCBI
HuRef2033,493,671 - 33,530,533 (-)NCBIHuRef
CHM1_12036,659,041 - 36,698,230 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status



Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on TGM2
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 732487
Created: 2004-01-12
Species: Homo sapiens
Last Modified: 2019-11-05
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.