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Gene: TRA2B (transformer 2 beta homolog) Homo sapiens
Symbol: TRA2B
Name: transformer 2 beta homolog
Description: Exhibits RNA binding activity; identical protein binding activity; and protein domain specific binding activity. Involved in several processes, including cellular response to glucose stimulus; mRNA splicing, via spliceosome; and regulation of mRNA splicing, via spliceosome. Localizes to the nucleoplasm and spliceosomal complex. Biomarker of macular degeneration.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: DKFZp686F18120; Htra2-beta; PPP1R156; SFRS10; splicing factor, arginine/serine-rich 10 (transformer 2 homolog, Drosophila); SRFS10; TRA-2 beta; TRA2-BETA; TRAN2B; transformer 2 beta homolog (Drosophila); transformer 2 homolog; transformer-2 protein homolog B; transformer-2 protein homolog beta; transformer-2-beta
Mus musculus (house mouse) : Tra2b (transformer 2 beta)  MGI  Alliance
Rattus norvegicus (Norway rat) : Tra2b (transformer 2 beta homolog)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Tra2b (transformer 2 beta homolog)
Pan paniscus (bonobo/pygmy chimpanzee) : TRA2B (transformer 2 beta homolog)
Canis lupus familiaris (dog) : TRA2B (transformer 2 beta homolog)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Tra2b (transformer 2 beta homolog)
Sus scrofa (pig) : TRA2B (transformer 2 beta homolog)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh383185,914,558 - 185,938,027 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh373185,632,356 - 185,655,924 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 363187,117,226 - 187,138,450 (-)NCBINCBI36hg18NCBI36
Build 343187,117,238 - 187,138,458NCBI
Celera3184,070,271 - 184,093,839 (-)NCBI
Cytogenetic Map3q27.2NCBI
HuRef3183,042,973 - 183,066,541 (-)NCBIHuRef
CHM1_13185,595,300 - 185,618,882 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status



Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on TRA2B
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 732515
Created: 2004-01-12
Species: Homo sapiens
Last Modified: 2019-11-26
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.