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Gene: CYSLTR1 (cysteinyl leukotriene receptor 1) Homo sapiens
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Symbol: CYSLTR1
Name: cysteinyl leukotriene receptor 1
Description: This gene encodes a member of the G-protein coupled receptor 1 family. The encoded protein is a receptor for cysteinyl leukotrienes, and is involved in mediating bronchoconstriction via activation of a phosphatidylinositol-calcium second messenger system. Activation of the encoded receptor results in contraction and proliferation of bronchial smooth muscle cells, eosinophil migration, and damage to the mucus layer in the lung. Upregulation of this gene is associated with asthma and dysregulation may also be implicated in cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: CYSLT1; CYSLT1R; CYSLTR; cysteinyl leukotriene D4 receptor; G-protein coupled receptor HG55; HG55; HMTMF81; LTD4 receptor; MGC46139
Orthologs:
Mus musculus (house mouse) : Cysltr1 (cysteinyl leukotriene receptor 1)  MGI  Alliance
Rattus norvegicus (Norway rat) : Cysltr1 (cysteinyl leukotriene receptor 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Cysltr1 (cysteinyl leukotriene receptor 1)
Pan paniscus (bonobo/pygmy chimpanzee) : CYSLTR1 (cysteinyl leukotriene receptor 1)
Canis lupus familiaris (dog) : CYSLTR1 (cysteinyl leukotriene receptor 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Cysltr1 (cysteinyl leukotriene receptor 1)
Sus scrofa (pig) : CYSLTR1 (cysteinyl leukotriene receptor 1)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X78,271,468 - 78,327,691 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37X77,526,965 - 77,583,193 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36X77,414,786 - 77,469,743 (-)NCBINCBI36hg18NCBI36
Build 34X77,334,275 - 77,389,232NCBI
CeleraX77,768,935 - 77,823,895 (-)NCBI
Cytogenetic MapXq21.1NCBI
HuRefX71,107,425 - 71,162,464 (-)NCBIHuRef
CHM1_1X77,420,045 - 77,476,269 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
 
More on CYSLTR1
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 732524
Created: 2004-01-12
Species: Homo sapiens
Last Modified: 2019-06-18
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.