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Gene: ERBB4 (erb-b2 receptor tyrosine kinase 4) Homo sapiens
Symbol: ERBB4
Name: erb-b2 receptor tyrosine kinase 4
CRRD ID: 732538
Description: Exhibits several functions, including epidermal growth factor receptor binding activity; protein homodimerization activity; and transmembrane receptor protein tyrosine kinase activity. Involved in several processes, including mitochondrial fragmentation involved in apoptotic process; positive regulation of phosphorylation; and protein phosphorylation. Localizes to several cellular components, including basolateral plasma membrane; mitochondrion; and receptor complex. Implicated in amyotrophic lateral sclerosis type 19 and colorectal cancer. Biomarker of ductal carcinoma in situ; prostate cancer; renal cell carcinoma; transitional cell carcinoma; and urinary bladder cancer.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: ALS19; avian erythroblastic leukemia viral (v-erb-b2) oncogene homolog 4; ERBB4 transcript variant I12DEL; ERBB4 transcript variant I20DEL; HER4; human epidermal growth factor receptor 4; MGC138404; p180erbB4; proto-oncogene-like protein c-ErbB-4; receptor tyrosine kinase; receptor tyrosine-protein kinase erbB-4; tyrosine kinase-type cell surface receptor HER4; v-erb-a erythroblastic leukemia viral oncogene homolog 4; v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 4
Mus musculus (house mouse) : Erbb4 (erb-b2 receptor tyrosine kinase 4)  MGI  Alliance
Rattus norvegicus (Norway rat) : Erbb4 (erb-b2 receptor tyrosine kinase 4)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Erbb4 (erb-b2 receptor tyrosine kinase 4)
Pan paniscus (bonobo/pygmy chimpanzee) : ERBB4 (erb-b2 receptor tyrosine kinase 4)
Canis lupus familiaris (dog) : ERBB4 (erb-b2 receptor tyrosine kinase 4)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Erbb4 (erb-b2 receptor tyrosine kinase 4)
Sus scrofa (pig) : ERBB4 (erb-b2 receptor tyrosine kinase 4)
Chlorocebus sabaeus (African green monkey) : ERBB4 (erb-b2 receptor tyrosine kinase 4)
Heterocephalus glaber (naked mole-rat) : Erbb4 (erb-b2 receptor tyrosine kinase 4)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38.p13 Ensembl2211,375,717 - 212,538,841 (-)EnsemblGRCh38hg38GRCh38
GRCh382211,375,717 - 212,538,802 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh372212,240,442 - 213,403,879 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362211,948,687 - 213,111,597 (-)NCBINCBI36hg18NCBI36
Build 342212,072,320 - 213,228,793NCBI
Celera2206,008,419 - 207,168,130 (-)NCBI
Cytogenetic Map2q34NCBI
HuRef2204,087,816 - 205,252,852 (-)NCBIHuRef
CHM1_12212,246,189 - 213,409,602 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on ERBB4
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 732538
Created: 2004-01-12
Species: Homo sapiens
Last Modified: 2020-11-10
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.