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Gene: Mfn2 (mitofusin 2) Mus musculus
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Symbol: Mfn2
Name: mitofusin 2
Description: Predicted to have several functions, including GTP binding activity; enzyme binding activity; and protein homodimerization activity. Involved in several processes, including mitochondrial fusion; parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization; and positive regulation of cold-induced thermogenesis. Localizes to the microtubule cytoskeleton and mitochondrion. Used to study Charcot-Marie-Tooth disease type 2A2. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease; Charcot-Marie-Tooth disease type 2A2; and Charcot-Marie-Tooth disease type 6. Is expressed in several structures, including brain; early conceptus; eye; heart; and oocyte. Orthologous to human MFN2 (mitofusin 2); PARTICIPATES IN mitochondria fusion pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 3,4-methylenedioxymethamphetamine; amiodarone.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: D630023P19Rik; Fzo; HSG protein; hypertension related protein 1; hypertension-related protein 1; mitochondrial assembly regulatory factor; mitofusin-2; transmembrane GTPase MFN2
Orthologs:
Homo sapiens (human) : MFN2 (mitofusin 2)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Mfn2 (mitofusin 2)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Mfn2 (mitofusin 2)
Pan paniscus (bonobo/pygmy chimpanzee) : MFN2 (mitofusin 2)
Canis lupus familiaris (dog) : MFN2 (mitofusin 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Mfn2 (mitofusin 2)
Sus scrofa (pig) : MFN2 (mitofusin 2)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm384147,873,586 - 147,904,909 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv374147,247,704 - 147,278,928 (-)NCBIGRCm37mm9NCBIm37
MGSCv364146,717,399 - 146,748,504 (-)NCBImm8
Celera4150,136,809 - 150,169,710 (-)NCBICelera
Cytogenetic Map4 E2NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters

Additional Information

External Database Links
 
More on Mfn2
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 732570
Created: 2004-01-12
Species: Mus musculus
Last Modified: 2019-10-29
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.