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Gene: Mfn2 (mitofusin 2) Mus musculus
Symbol: Mfn2
Name: mitofusin 2
Description: Predicted to have several functions, including GTP binding activity; enzyme binding activity; and protein homodimerization activity. Involved in several processes, including mitochondrial fusion; parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization; and positive regulation of cold-induced thermogenesis. Localizes to the microtubule cytoskeleton and mitochondrion. Used to study Charcot-Marie-Tooth disease type 2A2. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease; Charcot-Marie-Tooth disease type 2A2; and Charcot-Marie-Tooth disease type 6. Is expressed in several structures, including brain; early conceptus; eye; heart; and oocyte. Orthologous to human MFN2 (mitofusin 2); PARTICIPATES IN mitochondria fusion pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 3,4-methylenedioxymethamphetamine; amiodarone.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: D630023P19Rik; Fzo; HSG protein; hypertension related protein 1; hypertension-related protein 1; mitochondrial assembly regulatory factor; mitofusin-2; transmembrane GTPase MFN2
Homo sapiens (human) : MFN2 (mitofusin 2)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Mfn2 (mitofusin 2)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Mfn2 (mitofusin 2)
Pan paniscus (bonobo/pygmy chimpanzee) : MFN2 (mitofusin 2)
Canis lupus familiaris (dog) : MFN2 (mitofusin 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Mfn2 (mitofusin 2)
Sus scrofa (pig) : MFN2 (mitofusin 2)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm384147,873,586 - 147,904,909 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv374147,247,704 - 147,278,928 (-)NCBIGRCm37mm9NCBIm37
MGSCv364146,717,399 - 146,748,504 (-)NCBImm8
Celera4150,136,809 - 150,169,710 (-)NCBICelera
Cytogenetic Map4 E2NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Mfn2
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 732570
Created: 2004-01-12
Species: Mus musculus
Last Modified: 2019-10-29
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.