Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   
Gene: Cacnb2 (calcium channel, voltage-dependent, beta 2 subunit) Mus musculus
Symbol: Cacnb2
Name: calcium channel, voltage-dependent, beta 2 subunit
Description: Exhibits actin filament binding activity and voltage-gated calcium channel activity involved in positive regulation of presynaptic cytosolic calcium levels. Predicted to contribute to voltage-gated calcium channel activity involved in AV node cell action potential. Involved in chemical synaptic transmission and visual perception. Localizes to the photoreceptor ribbon synapse and voltage-gated calcium channel complex. Human ortholog(s) of this gene implicated in Brugada syndrome 4; hypertension; and hypertrophic cardiomyopathy. Is expressed in several structures, including brain; heart; ovary; retina layer; and spleen. Orthologous to human CACNB2 (calcium voltage-gated channel auxiliary subunit beta 2); PARTICIPATES IN calcium transport pathway; calcium/calcium-mediated signaling pathway; calcium/calmodulin dependent kinase 2 signaling pathway; INTERACTS WITH 4,4'-sulfonyldiphenol; benzo[a]pyrene; bisphenol F.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: AW060387; BC056183; CAB2; calcium channel beta 2 subunit; calcium channel voltage-dependent subunit beta 2; Cavbeta2; Cchb2; cDNA sequence BC056183; MGC129334; MGC129335; voltage-dependent L-type calcium channel subunit beta-2; voltage-gated calcium channel beta2 subunit transcript variant X13
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38214,603,861 - 14,988,811 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv37214,525,933 - 14,908,560 (+)NCBIGRCm37mm9NCBIm37
MGSCv36214,522,060 - 14,904,687 (+)NCBImm8
Celera214,505,146 - 14,889,329 (+)NCBICelera
Cytogenetic Map2 A2NCBI
cM Map210.7NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
Nomenclature History
More on Cacnb2
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 732577
Created: 2004-01-12
Species: Mus musculus
Last Modified: 2019-11-27
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.