Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   
Gene: Chrna3 (cholinergic receptor, nicotinic, alpha polypeptide 3) Mus musculus
Symbol: Chrna3
Name: cholinergic receptor, nicotinic, alpha polypeptide 3
Description: Exhibits acetylcholine-gated cation-selective channel activity. Predicted to contribute to acetylcholine binding activity and acetylcholine receptor activity. Involved in several processes, including activation of transmembrane receptor protein tyrosine kinase activity; behavioral response to nicotine; and chemical synaptic transmission. Localizes to acetylcholine-gated channel complex; cholinergic synapse; and integral component of postsynaptic specialization membrane. Human ortholog(s) of this gene implicated in lung cancer. Is expressed in several structures, including central nervous system; gut; paravertebral ganglion; retina; and trigeminal nerve. Orthologous to human CHRNA3 (cholinergic receptor nicotinic alpha 3 subunit); PARTICIPATES IN acetylcholine signaling pathway via nicotinic acetylcholine receptor; nicotine pharmacodynamics pathway; nicotine pharmacokinetics pathway; INTERACTS WITH (S)-nicotine; 1,2-dichloroethane; 2,2',4,4',5,5'-hexachlorobiphenyl.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: (a)3; A730007P14Rik; Acra-3; Acra3; alpha 3; neuronal acetylcholine receptor subunit alpha-3; neuronal nicotinic acetylcholine receptor, alpha 3 subunit
Homo sapiens (human) : CHRNA3 (cholinergic receptor nicotinic alpha 3 subunit)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Chrna3 (cholinergic receptor nicotinic alpha 3 subunit)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Chrna3 (cholinergic receptor nicotinic alpha 3 subunit)
Pan paniscus (bonobo/pygmy chimpanzee) : CHRNA3 (cholinergic receptor nicotinic alpha 3 subunit)
Canis lupus familiaris (dog) : CHRNA3 (cholinergic receptor nicotinic alpha 3 subunit)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Chrna3 (cholinergic receptor nicotinic alpha 3 subunit)
Sus scrofa (pig) : CHRNA3 (cholinergic receptor nicotinic alpha 3 subunit)
Chlorocebus sabaeus (African green monkey) : CHRNA3 (cholinergic receptor nicotinic alpha 3 subunit)
Heterocephalus glaber (naked mole-rat) : Chrna3 (cholinergic receptor nicotinic alpha 3 subunit)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38 Ensembl955,010,111 - 55,026,562 (-)EnsemblGRCm38mm10GRCm38
GRCm38955,010,117 - 55,026,562 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv37954,859,150 - 54,874,366 (-)NCBIGRCm37mm9NCBIm37
MGSCv36954,809,480 - 54,824,696 (-)NCBImm8
Celera952,254,751 - 52,269,961 (-)NCBICelera
Cytogenetic Map9BNCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Chrna3
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 732614
Created: 2004-01-12
Species: Mus musculus
Last Modified: 2020-05-05
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.