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Gene: Chrna3 (cholinergic receptor, nicotinic, alpha polypeptide 3) Mus musculus
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Symbol: Chrna3
Name: cholinergic receptor, nicotinic, alpha polypeptide 3
Description: Exhibits acetylcholine-gated cation-selective channel activity. Predicted to contribute to acetylcholine binding activity and acetylcholine receptor activity. Involved in several processes, including activation of transmembrane receptor protein tyrosine kinase activity; behavioral response to nicotine; and chemical synaptic transmission. Localizes to acetylcholine-gated channel complex; cholinergic synapse; and integral component of postsynaptic specialization membrane. Human ortholog(s) of this gene implicated in lung cancer. Is expressed in several structures, including central nervous system; gut; paravertebral ganglion; retina; and trigeminal nerve. Orthologous to human CHRNA3 (cholinergic receptor nicotinic alpha 3 subunit); PARTICIPATES IN acetylcholine signaling pathway via nicotinic acetylcholine receptor; nicotine pharmacodynamics pathway; nicotine pharmacokinetics pathway; INTERACTS WITH (S)-nicotine; 1,2-dichloroethane; 2,2',4,4',5,5'-hexachlorobiphenyl.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: (a)3; A730007P14Rik; Acra-3; Acra3; alpha 3; neuronal acetylcholine receptor subunit alpha-3; neuronal nicotinic acetylcholine receptor, alpha 3 subunit
Orthologs:
Homo sapiens (human) : CHRNA3 (cholinergic receptor nicotinic alpha 3 subunit)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Chrna3 (cholinergic receptor nicotinic alpha 3 subunit)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Chrna3 (cholinergic receptor nicotinic alpha 3 subunit)
Pan paniscus (bonobo/pygmy chimpanzee) : CHRNA3 (cholinergic receptor nicotinic alpha 3 subunit)
Canis lupus familiaris (dog) : CHRNA3 (cholinergic receptor nicotinic alpha 3 subunit)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Chrna3 (cholinergic receptor nicotinic alpha 3 subunit)
Sus scrofa (pig) : CHRNA3 (cholinergic receptor nicotinic alpha 3 subunit)
Chlorocebus sabaeus (African green monkey) : CHRNA3 (cholinergic receptor nicotinic alpha 3 subunit)
Heterocephalus glaber (naked mole-rat) : Chrna3 (cholinergic receptor nicotinic alpha 3 subunit)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm38 Ensembl955,010,111 - 55,026,562 (-)EnsemblGRCm38mm10GRCm38
GRCm38955,010,117 - 55,026,562 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv37954,859,150 - 54,874,366 (-)NCBIGRCm37mm9NCBIm37
MGSCv36954,809,480 - 54,824,696 (-)NCBImm8
Celera952,254,751 - 52,269,961 (-)NCBICelera
Cytogenetic Map9BNCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
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Molecular Pathway Annotations
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References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters

Additional Information

External Database Links
 
More on Chrna3
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 732614
Created: 2004-01-12
Species: Mus musculus
Last Modified: 2020-05-05
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.