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Gene: EGLN3 (egl-9 family hypoxia inducible factor 3) Homo sapiens
Symbol: EGLN3
Name: egl-9 family hypoxia inducible factor 3
CRRD ID: 732652
Description: Exhibits peptidyl-proline 4-dioxygenase activity. Involved in several processes, including activation of cysteine-type endopeptidase activity involved in apoptotic process; peptidyl-proline hydroxylation to 4-hydroxy-L-proline; and response to hypoxia. Localizes to cytosol and nucleus. Implicated in renal cell carcinoma. Biomarker of clear cell renal cell carcinoma; PARTICIPATES IN hypoxia inducible factor pathway; renal cell carcinoma pathway; vascular endothelial growth factor signaling pathway; INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; aflatoxin B1.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: egl nine homolog 3; egl nine-like protein 3 isoform; egl-9 family hypoxia-inducible factor 3; FLJ21620; HIF prolyl hydroxylase 3; HIF-PH3; HIF-prolyl hydroxylase 3; HIFP4H3; HIFPH3; HPH-1; HPH-3; hypoxia-inducible factor prolyl hydroxylase 3; MGC125998; MGC125999; PHD3; prolyl hydroxylase domain-containing protein 3; prolyl hydroxylase EGLN3
Mus musculus (house mouse) : Egln3 (egl-9 family hypoxia-inducible factor 3)  MGI  Alliance
Rattus norvegicus (Norway rat) : Egln3 (egl-9 family hypoxia-inducible factor 3)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Egln3 (egl-9 family hypoxia inducible factor 3)
Pan paniscus (bonobo/pygmy chimpanzee) : EGLN3 (egl-9 family hypoxia inducible factor 3)
Canis lupus familiaris (dog) : EGLN3 (egl-9 family hypoxia inducible factor 3)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Egln3 (egl-9 family hypoxia inducible factor 3)
Sus scrofa (pig) : EGLN3 (egl-9 family hypoxia inducible factor 3)
Chlorocebus sabaeus (African green monkey) : EGLN3 (egl-9 family hypoxia inducible factor 3)
Heterocephalus glaber (naked mole-rat) : Egln3 (egl-9 family hypoxia inducible factor 3)
more info ...
Related Pseudogenes: EGLN3P1  
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38.p13 Ensembl1433,924,227 - 34,462,774 (-)EnsemblGRCh38hg38GRCh38
GRCh381433,924,227 - 33,951,074 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371434,393,421 - 34,420,284 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361433,463,172 - 33,490,035 (-)NCBINCBI36hg18NCBI36
Build 341433,463,172 - 33,490,037NCBI
Celera1414,258,646 - 14,285,539 (-)NCBI
Cytogenetic Map14q13.1NCBI
HuRef1414,510,074 - 14,536,960 (-)NCBIHuRef
CHM1_11434,391,710 - 34,418,579 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on EGLN3
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 732652
Created: 2004-01-12
Species: Homo sapiens
Last Modified: 2020-09-16
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.