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Gene: Pdpk1 (3-phosphoinositide dependent protein kinase 1) Mus musculus
Symbol: Pdpk1
Name: 3-phosphoinositide dependent protein kinase 1
CRRD ID: 732665
Description: Exhibits 3-phosphoinositide-dependent protein kinase activity. Involved in several processes, including negative regulation of cardiac muscle cell apoptotic process; regulation of mast cell degranulation; and type B pancreatic cell development. Localizes to cytoplasmic vesicle and postsynaptic density. Is expressed in several structures, including central nervous system; extraembryonic component; genitourinary system; hemolymphoid system gland; and retina. Human ortholog(s) of this gene implicated in prostate cancer. Orthologous to several human genes including PDPK1 (3-phosphoinositide dependent protein kinase 1); PARTICIPATES IN adenosine signaling pathway; angiotensin II signaling pathway; FasL mediated signaling pathway; INTERACTS WITH 1,2-dichloroethane; 1,2-dimethylhydrazine; 17alpha-ethynylestradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 3-phosphoinositide dependent protein kinase-1; 3-phosphoinositide-dependent protein kinase 1; mPDK1; Pdk; Pdk1; Pkb kinase
Homo sapiens (human) : PDPK1 (3-phosphoinositide dependent protein kinase 1)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Pdpk1 (3-phosphoinositide dependent protein kinase-1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Pdpk1 (3-phosphoinositide dependent protein kinase 1)
Pan paniscus (bonobo/pygmy chimpanzee) : PDPK1 (3-phosphoinositide dependent protein kinase 1)
Canis lupus familiaris (dog) : PDPK1 (3-phosphoinositide dependent protein kinase 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Pdpk1 (3-phosphoinositide dependent protein kinase 1)
Sus scrofa (pig) : PDPK1 (3-phosphoinositide dependent protein kinase 1)
Chlorocebus sabaeus (African green monkey) : PDPK1 (3-phosphoinositide dependent protein kinase 1)
Heterocephalus glaber (naked mole-rat) : Pdpk1 (3-phosphoinositide dependent protein kinase 1)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
NCBI Annotation Information: Note: Pdk1 (Gene ID: 228026) and Pdpk1 (Gene ID: 18607) share the Pdk1 symbol/alias in common. Pdk1 is a widely used alternative name for 3-phosphoinositide dependent protein kinase 1 (Pdpk1), which can be confused with the official symbol for pyruvate dehydrogenase kinase, isoenzyme 1 (Pdk1). [03 Apr 2019]
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm391724,292,654 - 24,370,957 (-)NCBI
GRCm381724,073,680 - 24,155,619 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1724,073,680 - 24,150,924 (-)EnsemblGRCm38mm10GRCm38
MGSCv371724,210,647 - 24,278,561 (-)NCBIGRCm37mm9NCBIm37
MGSCv361723,806,503 - 23,869,181 (-)NCBImm8
Celera1724,579,774 - 24,646,541 (-)NCBICelera
Cytogenetic Map17A3.3NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
Nomenclature History
More on Pdpk1
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 732665
Created: 2004-01-12
Species: Mus musculus
Last Modified: 2020-10-27
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.