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Gene: LYN (LYN proto-oncogene, Src family tyrosine kinase) Homo sapiens
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Symbol: LYN
Name: LYN proto-oncogene, Src family tyrosine kinase
Description: Exhibits several functions, including ephrin receptor binding activity; ion channel binding activity; and phosphorylation-dependent protein binding activity. Involved in several processes, including cellular response to retinoic acid; positive regulation of cellular protein metabolic process; and protein phosphorylation. Localizes to several cellular components, including the Golgi apparatus; membrane raft; and perinuclear region of cytoplasm.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: FLJ26625; JTK8; lck/Yes-related novel protein tyrosine kinase; lyn protein non-receptor kinase; p53Lyn; p56Lyn; tyrosine-protein kinase Lyn; v-yes-1 Yamaguchi sarcoma viral related oncogene homolog; Yamaguchi sarcoma viral (v-yes-1) related oncogene homolog
Orthologs:
Mus musculus (house mouse) : Lyn (LYN proto-oncogene, Src family tyrosine kinase)  MGI  Alliance
Rattus norvegicus (Norway rat) : Lyn (LYN proto-oncogene, Src family tyrosine kinase)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Lyn (LYN proto-oncogene, Src family tyrosine kinase)
Pan paniscus (bonobo/pygmy chimpanzee) : LYN (LYN proto-oncogene, Src family tyrosine kinase)
Canis lupus familiaris (dog) : LYN (LYN proto-oncogene, Src family tyrosine kinase)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Lyn (LYN proto-oncogene, Src family tyrosine kinase)
Sus scrofa (pig) : LYN (LYN proto-oncogene, Src family tyrosine kinase)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38855,876,041 - 56,014,169 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37856,792,386 - 56,925,006 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36856,954,926 - 57,085,685 (+)NCBINCBI36hg18NCBI36
Build 34856,954,925 - 57,085,685NCBI
Celera852,784,229 - 52,915,775 (+)NCBI
Cytogenetic Map8q12.1NCBI
HuRef852,260,576 - 52,393,067 (+)NCBIHuRef
CHM1_1856,844,030 - 56,976,630 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
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References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
Nomenclature History
 
More on LYN
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 732668
Created: 2004-01-12
Species: Homo sapiens
Last Modified: 2019-11-26
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.