Gene: LYN (LYN proto-oncogene, Src family tyrosine kinase) Homo sapiens
Analyze
Symbol:
LYN
Name:
LYN proto-oncogene, Src family tyrosine kinase
Description:
Exhibits several functions, including ephrin receptor binding activity; ion channel binding activity; and phosphorylation-dependent protein binding activity. Involved in several processes, including cellular response to retinoic acid; positive regulation of cellular protein metabolic process; and protein phosphorylation. Localizes to several cellular components, including the Golgi apparatus; membrane raft; and perinuclear region of cytoplasm.
Type:
protein-coding
RefSeq Status:
REVIEWED
Also known as:
FLJ26625; JTK8; lck/Yes-related novel protein tyrosine kinase; lyn protein non-receptor kinase; p53Lyn; p56Lyn; tyrosine-protein kinase Lyn; v-yes-1 Yamaguchi sarcoma viral related oncogene homolog; Yamaguchi sarcoma viral (v-yes-1) related oncogene homolog
Orthologs:
Species
Gene symbol and name
Data Source
Assertion derived from
less info ...
Orthologs 1
Mus musculus (house mouse):
Lyn (LYN proto-oncogene, Src family tyrosine kinase)
HGNC
EggNOG, Ensembl, HGNC, HomoloGene, Inparanoid, NCBI, OMA, Panther, PhylomeDB, Treefam
Rattus norvegicus (Norway rat):
Lyn (LYN proto-oncogene, Src family tyrosine kinase)
HGNC
EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, Panther, PhylomeDB, Treefam
Chinchilla lanigera (long-tailed chinchilla):
Lyn (LYN proto-oncogene, Src family tyrosine kinase)
NCBI
Ortholog
Pan paniscus (bonobo/pygmy chimpanzee):
LYN (LYN proto-oncogene, Src family tyrosine kinase)
NCBI
Ortholog
Canis lupus familiaris (dog):
LYN (LYN proto-oncogene, Src family tyrosine kinase)
HGNC
EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, Panther, Treefam
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):
Lyn (LYN proto-oncogene, Src family tyrosine kinase)
NCBI
Ortholog
Sus scrofa (pig):
LYN (LYN proto-oncogene, Src family tyrosine kinase)
HGNC
EggNOG, Ensembl, NCBI, OMA, OrthoDB, Panther, Treefam
Alliance orthologs 3
Rattus norvegicus (Norway rat):
Lyn (LYN proto-oncogene, Src family tyrosine kinase)
Alliance
DIOPT (Ensembl Compara, HGNC, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, TreeFam)
Mus musculus (house mouse):
Lyn (LYN proto-oncogene, Src family tyrosine kinase)
Alliance
DIOPT (Ensembl Compara, HGNC, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, Roundup, TreeFam)
Danio rerio (zebrafish):
lyn (LYN proto-oncogene, Src family tyrosine kinase)
Alliance
DIOPT (Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, Roundup, TreeFam, ZFIN)
Drosophila melanogaster (fruit fly):
Src64B
Alliance
DIOPT (Ensembl Compara, OrthoFinder, PANTHER, PhylomeDB)
Caenorhabditis elegans (roundworm):
Y47G6A.5
Alliance
DIOPT (OrthoFinder, PANTHER, PhylomeDB)
Caenorhabditis elegans (roundworm):
src-1
Alliance
DIOPT (Ensembl Compara, InParanoid, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB)
Allele / Splice:
See ClinVar data
Latest Assembly:
GRCh38 - Human Genome Assembly GRCh38
Position:
Human Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl GRCh38 8 55,876,041 - 56,014,169 (+) NCBI GRCh38 GRCh38 hg38 GRCh38 GRCh37 8 56,792,386 - 56,925,006 (+) NCBI GRCh37 GRCh37 hg19 GRCh37 Build 36 8 56,954,926 - 57,085,685 (+) NCBI NCBI36 hg18 NCBI36 Build 34 8 56,954,925 - 57,085,685 NCBI Celera 8 52,784,229 - 52,915,775 (+) NCBI Cytogenetic Map 8 q12.1 NCBI HuRef 8 52,260,576 - 52,393,067 (+) NCBI HuRef CHM1_1 8 56,844,030 - 56,976,630 (+) NCBI CHM1_1
JBrowse:
View Region in Genome Browser (JBrowse)
Model
Disease Annotations
Imported Annotations - CTD
human immunodeficiency virus infectious disease EXP 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:15308739
Imported Annotations - MGI
systemic lupus erythematosus ISS RGD:732669 13592920 OMIM:152700 more ... MouseDO
(+)-alpha-tocopherol multiple interactions EXP 6480464 alpha-Tocopherol inhibits the reaction [bis(2-hydroxy-2-ethylbutanoato)oxochromate(V) results in increased phosphorylation of LYN protein], alpha-Tocopherol inhibits the reaction [Potassium Dichromate results in increased phosphorylation of LYN protein] CTD PMID:14572611 (+)-catechin decreases expression EXP 6480464 Catechin results in decreased expression of LYN mRNA CTD PMID:15465739 17alpha-ethynylestradiol increases expression ISO RGD:732669 6480464 Ethinyl Estradiol results in increased expression of LYN mRNA CTD PMID:17555576 17alpha-ethynylestradiol increases expression ISO RGD:621017 6480464 Ethinyl Estradiol results in increased expression of LYN mRNA CTD PMID:15834898 , PMID:17557909 17beta-estradiol multiple interactions EXP 6480464 [Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of LYN mRNA, [Raloxifene Hydrochloride co-treated with Estradiol] results in increased expression of LYN mRNA CTD PMID:19619570 , PMID:21185374 17beta-estradiol decreases expression EXP 6480464 Estradiol results in decreased expression of LYN mRNA CTD PMID:19619570 2,3,7,8-tetrachlorodibenzodioxine decreases expression EXP 6480464 Tetrachlorodibenzodioxin results in decreased expression of LYN mRNA CTD PMID:19619570 2,3,7,8-tetrachlorodibenzodioxine increases expression EXP 6480464 Tetrachlorodibenzodioxin results in increased expression of LYN mRNA CTD PMID:20106945 , PMID:21632981 2,3,7,8-tetrachlorodibenzodioxine increases expression ISO RGD:621017 6480464 Tetrachlorodibenzodioxin results in increased expression of LYN mRNA CTD PMID:21215274 2,3,7,8-tetrachlorodibenzodioxine affects expression ISO RGD:621017 6480464 Tetrachlorodibenzodioxin affects the expression of LYN mRNA CTD PMID:22298810 2,3,7,8-tetrachlorodibenzodioxine multiple interactions EXP 6480464 [Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of LYN mRNA CTD PMID:19619570 2,3,7,8-tetrachlorodibenzodioxine affects expression ISO RGD:732669 6480464 Tetrachlorodibenzodioxin affects the expression of LYN mRNA CTD PMID:20702594 2-ethoxyethanol increases expression ISO RGD:621017 6480464 2-ethoxyethanol results in increased expression of LYN mRNA CTD PMID:19643169 2-methoxyethanol increases expression ISO RGD:621017 6480464 methyl cellosolve results in increased expression of LYN mRNA CTD PMID:19643169 3,3',4,4',5-pentachlorobiphenyl affects expression ISO RGD:732669 6480464 3 more ... CTD PMID:20702594 3,3',4,4',5-pentachlorobiphenyl increases expression ISO RGD:621017 6480464 3 more ... CTD PMID:23196670 4,4'-sulfonyldiphenol increases expression ISO RGD:732669 6480464 bis(4-hydroxyphenyl)sulfone results in increased expression of LYN mRNA CTD PMID:30951980 4-hydroxynon-2-enal decreases expression ISO RGD:732669 6480464 4-hydroxy-2-nonenal results in decreased expression of LYN mRNA CTD PMID:19191707 4-hydroxynon-2-enal decreases expression EXP 6480464 4-hydroxy-2-nonenal results in decreased expression of LYN mRNA CTD PMID:12419474 acetylsalicylic acid increases expression EXP 6480464 Aspirin results in increased expression of LYN mRNA CTD PMID:15928584 afimoxifene decreases response to substance EXP 6480464 LYN results in decreased susceptibility to afimoxifene CTD PMID:21233418 all-trans-retinoic acid decreases expression EXP 6480464 Tretinoin results in decreased expression of LYN mRNA CTD PMID:21934132 all-trans-retinoic acid increases expression EXP 6480464 Tretinoin results in increased expression of LYN mRNA CTD PMID:12875902 , PMID:15498508 aluminium trifluoride increases phosphorylation ISO RGD:732669 6480464 aluminum fluoride results in increased phosphorylation of LYN protein CTD PMID:8559152 alvocidib multiple interactions EXP 6480464 [alvocidib co-treated with Bortezomib co-treated with ABL1 protein] results in decreased phosphorylation of LYN protein CTD PMID:15039284 ammonium chloride affects expression ISO RGD:621017 6480464 Ammonium Chloride affects the expression of LYN mRNA CTD PMID:16483693 antigen increases activity ISO RGD:732669 6480464 Antigens results in increased activity of LYN protein CTD PMID:21958720 antigen multiple interactions ISO RGD:732669 6480464 Quinoxalines analog affects the reaction [Antigens results in increased activity of LYN protein] CTD PMID:21958720 antirheumatic drug decreases expression EXP 6480464 Antirheumatic Agents results in decreased expression of LYN mRNA CTD PMID:24449571 benzamide decreases activity EXP 6480464 benzamide analog results in decreased activity of LYN protein CTD PMID:17376680 benzene increases expression EXP 6480464 Benzene results in increased expression of LYN mRNA CTD PMID:16188089 benzo[a]pyrene decreases expression ISO RGD:732669 6480464 Benzo(a)pyrene results in decreased expression of LYN mRNA CTD PMID:21569818 benzo[a]pyrene diol epoxide I decreases expression EXP 6480464 7 more ... CTD PMID:19150397 , PMID:20018196 bis(2-ethylhexyl) phthalate increases expression EXP 6480464 Diethylhexyl Phthalate results in increased expression of LYN mRNA CTD PMID:31163220 bisphenol A decreases expression ISO RGD:621017 6480464 bisphenol A results in decreased expression of LYN mRNA CTD PMID:25181051 bisphenol A increases methylation ISO RGD:621017 6480464 bisphenol A results in increased methylation of LYN gene CTD PMID:28505145 bortezomib multiple interactions EXP 6480464 [alvocidib co-treated with Bortezomib co-treated with ABL1 protein] results in decreased phosphorylation of LYN protein CTD PMID:15039284 bosutinib decreases activity ISO RGD:621017 6480464 bosutinib results in decreased activity of LYN protein CTD PMID:17114238 butan-1-ol multiple interactions EXP 6480464 [[Gasoline co-treated with 1-Butanol] results in increased chemical synthesis of [Particulate Matter co-treated with Polycyclic Aromatic Hydrocarbons]] which results in increased expression of LYN mRNA CTD PMID:29432896 calcitriol increases expression EXP 6480464 Calcitriol results in increased expression of LYN mRNA CTD PMID:12875902 chromium(6+) affects expression ISO RGD:732669 6480464 chromium hexavalent ion affects the expression of LYN mRNA CTD PMID:28472532 cisplatin decreases expression EXP 6480464 Cisplatin results in decreased expression of LYN mRNA CTD PMID:21603599 copper(II) sulfate increases expression EXP 6480464 Copper Sulfate results in increased expression of LYN mRNA CTD PMID:19549813 coumestrol decreases expression EXP 6480464 Coumestrol results in decreased expression of LYN mRNA CTD PMID:19167446 cytarabine decreases expression EXP 6480464 Cytarabine results in decreased expression of LYN mRNA CTD PMID:21198554 dexamethasone affects expression EXP 6480464 Dexamethasone affects the expression of LYN mRNA CTD PMID:12732289 dexamethasone increases phosphorylation ISO RGD:621017 6480464 Dexamethasone results in increased phosphorylation of LYN protein CTD PMID:15187100 diazinon increases methylation EXP 6480464 Diazinon results in increased methylation of LYN gene CTD PMID:22964155 dichlorine multiple interactions ISO RGD:621017 6480464 [Ozone co-treated with Chlorine] results in increased expression of LYN mRNA CTD PMID:18636392 dichlorine increases expression ISO RGD:621017 6480464 Chlorine results in increased expression of LYN mRNA CTD PMID:18636392 diethylstilbestrol increases expression EXP 6480464 Diethylstilbestrol results in increased expression of LYN mRNA CTD PMID:15766595 dorsomorphin multiple interactions EXP 6480464 [NOG protein co-treated with entinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1 more ... CTD PMID:27188386 doxorubicin decreases expression EXP 6480464 Doxorubicin results in decreased expression of LYN mRNA CTD PMID:29803840 entinostat increases expression EXP 6480464 entinostat results in increased expression of LYN mRNA CTD PMID:26272509 entinostat multiple interactions EXP 6480464 [NOG protein co-treated with entinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of LYN mRNA CTD PMID:27188386 ethanol decreases expression ISO RGD:621017 6480464 Ethanol results in decreased expression of LYN mRNA CTD PMID:15353170 ethanol increases expression ISO RGD:732669 6480464 Ethanol results in increased expression of LYN mRNA CTD PMID:30319688 ethanol multiple interactions ISO RGD:621017 6480464 Ethanol results in increased expression of [ITGA2 protein binds to LYN protein binds to TRPV4 protein] CTD PMID:18234883 flutamide increases expression ISO RGD:621017 6480464 Flutamide results in increased expression of LYN mRNA CTD PMID:24136188 flutamide decreases expression ISO RGD:621017 6480464 Flutamide results in decreased expression of LYN mRNA CTD PMID:24793618 glutathione multiple interactions EXP 6480464 Glutathione inhibits the reaction [bis(2-hydroxy-2-ethylbutanoato)oxochromate(V) results in increased phosphorylation of LYN protein], Glutathione inhibits the reaction [Potassium Dichromate results in increased phosphorylation of LYN protein] CTD PMID:14572611 Honokiol multiple interactions EXP 6480464 honokiol inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased phosphorylation of LYN protein] CTD PMID:25980585 indometacin decreases expression EXP 6480464 Indomethacin results in decreased expression of LYN mRNA CTD PMID:16984733 isotretinoin increases expression EXP 6480464 Isotretinoin results in increased expression of LYN mRNA CTD PMID:20436886 L-ascorbic acid multiple interactions EXP 6480464 Ascorbic Acid inhibits the reaction [bis(2-hydroxy-2-ethylbutanoato)oxochromate(V) results in increased phosphorylation of LYN protein], Ascorbic Acid inhibits the reaction [Potassium Dichromate results in increased phosphorylation of LYN protein] CTD PMID:14572611 leflunomide increases expression ISO RGD:621017 6480464 leflunomide results in increased expression of LYN mRNA CTD PMID:24136188 manganese(II) chloride decreases methylation EXP 6480464 manganese chloride results in decreased methylation of LYN gene CTD PMID:27913844 mercury atom multiple interactions ISO RGD:732669 6480464 Mercury results in increased phosphorylation of and results in increased activity of LYN protein CTD PMID:24440445 mercury(0) multiple interactions ISO RGD:732669 6480464 Mercury results in increased phosphorylation of and results in increased activity of LYN protein CTD PMID:24440445 methyl methanesulfonate decreases expression EXP 6480464 Methyl Methanesulfonate results in decreased expression of LYN mRNA CTD PMID:23649840 methylmercury chloride decreases expression EXP 6480464 methylmercuric chloride results in decreased expression of LYN mRNA CTD PMID:23179753 methylmercury chloride multiple interactions EXP 6480464 [NOG protein co-treated with methylmercuric chloride co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of LYN mRNA CTD PMID:27188386 methylmercury chloride increases expression EXP 6480464 methylmercuric chloride results in increased expression of LYN mRNA CTD PMID:26272509 , PMID:28001369 mycophenolic acid multiple interactions EXP 6480464 [Mycophenolic Acid co-treated with Imatinib Mesylate] results in decreased phosphorylation of LYN protein CTD PMID:15604220 N-formyl-L-methionyl-L-leucyl-L-phenylalanine multiple interactions EXP 6480464 AG 1879 inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased phosphorylation of LYN protein], honokiol inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased phosphorylation of LYN protein] CTD PMID:25980585 N-formyl-L-methionyl-L-leucyl-L-phenylalanine increases phosphorylation EXP 6480464 N-Formylmethionine Leucyl-Phenylalanine results in increased phosphorylation of LYN protein CTD PMID:25980585 nickel atom increases expression EXP 6480464 Nickel results in increased expression of LYN mRNA CTD PMID:24768652 , PMID:25583101 nickel dichloride affects expression ISO RGD:621017 6480464 nickel chloride affects the expression of LYN mRNA CTD PMID:22546817 nickel sulfate increases expression EXP 6480464 nickel sulfate results in increased expression of LYN mRNA CTD PMID:22714537 oxaliplatin multiple interactions ISO RGD:621017 6480464 [oxaliplatin co-treated with Topotecan] results in decreased expression of LYN mRNA CTD PMID:25729387 ozone multiple interactions ISO RGD:621017 6480464 [Ozone co-treated with Chlorine] results in increased expression of LYN mRNA CTD PMID:18636392 ozone decreases expression ISO RGD:621017 6480464 Ozone results in decreased expression of LYN mRNA CTD PMID:16330353 panobinostat increases expression EXP 6480464 panobinostat results in increased expression of LYN mRNA CTD PMID:26272509 panobinostat multiple interactions EXP 6480464 [NOG protein co-treated with Panobinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of LYN mRNA CTD PMID:27188386 paracetamol increases expression EXP 6480464 Acetaminophen results in increased expression of LYN mRNA CTD PMID:26690555 phenylmercury acetate increases expression EXP 6480464 Phenylmercuric Acetate results in increased expression of LYN mRNA CTD PMID:26272509 phenylmercury acetate multiple interactions EXP 6480464 [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of LYN mRNA CTD PMID:27188386 phosgene affects expression ISO RGD:732669 6480464 Phosgene affects the expression of LYN mRNA CTD PMID:16300373 pirinixic acid decreases expression ISO RGD:732669 6480464 pirinixic acid results in decreased expression of LYN mRNA CTD PMID:18445702 ponatinib decreases activity EXP 6480464 ponatinib results in decreased activity of LYN protein CTD PMID:19878872 potassium chromate increases expression EXP 6480464 potassium chromate(VI) results in increased expression of LYN mRNA CTD PMID:22714537 potassium dichromate multiple interactions EXP 6480464 AG 1879 inhibits the reaction [Potassium Dichromate results in increased phosphorylation of LYN protein] more ... CTD PMID:14572611 potassium dichromate increases phosphorylation EXP 6480464 Potassium Dichromate results in increased phosphorylation of LYN protein CTD PMID:14572611 quercetin increases expression EXP 6480464 Quercetin results in increased expression of LYN mRNA CTD PMID:21632981 raloxifene multiple interactions EXP 6480464 [Raloxifene Hydrochloride co-treated with Estradiol] results in increased expression of LYN mRNA CTD PMID:21185374 SB 431542 increases expression EXP 6480464 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in increased expression of LYN protein CTD PMID:25670856 SB 431542 multiple interactions EXP 6480464 [NOG protein co-treated with entinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1 more ... CTD PMID:27188386 silicon dioxide increases expression EXP 6480464 Silicon Dioxide results in increased expression of LYN mRNA CTD PMID:25351596 Soman increases expression ISO RGD:621017 6480464 Soman results in increased expression of LYN mRNA CTD PMID:19281266 tamibarotene increases expression EXP 6480464 tamibarotene results in increased expression of LYN mRNA CTD PMID:15498508 tamoxifen affects expression ISO RGD:732669 6480464 Tamoxifen affects the expression of LYN mRNA CTD PMID:17555576 taurine decreases expression EXP 6480464 Taurine results in decreased expression of LYN mRNA CTD PMID:16579726 tert-butyl hydroperoxide decreases expression EXP 6480464 tert-Butylhydroperoxide results in decreased expression of LYN mRNA CTD PMID:12419474 topotecan multiple interactions ISO RGD:621017 6480464 [oxaliplatin co-treated with Topotecan] results in decreased expression of LYN mRNA CTD PMID:25729387 topotecan decreases expression ISO RGD:621017 6480464 Topotecan results in decreased expression of LYN mRNA CTD PMID:25729387 trichostatin A increases expression EXP 6480464 trichostatin A results in increased expression of LYN mRNA CTD PMID:24935251 , PMID:26272509 trichostatin A multiple interactions EXP 6480464 [NOG protein co-treated with trichostatin A co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of LYN mRNA CTD PMID:27188386 triptonide decreases expression EXP 6480464 triptonide results in decreased expression of LYN mRNA CTD PMID:28666825 triptonide multiple interactions EXP 6480464 triptonide results in decreased expression of and results in decreased phosphorylation of LYN protein CTD PMID:28666825 tunicamycin decreases expression EXP 6480464 Tunicamycin results in decreased expression of LYN mRNA CTD PMID:22378314 urethane increases expression EXP 6480464 Urethane results in increased expression of LYN mRNA CTD PMID:28818685 valproic acid affects expression EXP 6480464 Valproic Acid affects the expression of LYN mRNA CTD PMID:25979313 valproic acid multiple interactions EXP 6480464 [NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of LYN mRNA CTD PMID:27188386 valproic acid increases expression EXP 6480464 Valproic Acid results in increased expression of LYN mRNA CTD PMID:23179753 more ... vancomycin decreases expression ISO RGD:732669 6480464 Vancomycin results in decreased expression of LYN mRNA CTD PMID:18930951 vitamin E multiple interactions EXP 6480464 alpha-Tocopherol inhibits the reaction [bis(2-hydroxy-2-ethylbutanoato)oxochromate(V) results in increased phosphorylation of LYN protein], alpha-Tocopherol inhibits the reaction [Potassium Dichromate results in increased phosphorylation of LYN protein] CTD PMID:14572611 vitamin E decreases expression EXP 6480464 Vitamin E results in decreased expression of LYN mRNA CTD PMID:19244175 vorinostat multiple interactions EXP 6480464 [NOG protein co-treated with Vorinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of LYN mRNA CTD PMID:27188386 vorinostat increases expression EXP 6480464 vorinostat results in increased expression of LYN mRNA CTD PMID:26272509 zinc oxide multiple interactions ISO RGD:732669 6480464 Zinc Oxide analog promotes the reaction [OVAL protein results in increased phosphorylation of LYN protein] CTD PMID:25127755 zoledronic acid increases expression EXP 6480464 zoledronic acid results in increased expression of LYN mRNA CTD PMID:24714768
Biological Process
adaptive immune response IEA UniProtKB-KW:KW-1064 2290271 UniProtKB GO_REF:0000037 B cell homeostasis ISS UniProtKB:P25911 2290271 UniProtKB GO_REF:0000024 B cell receptor signaling pathway IEA UniProtKB:P25911 , ensembl:ENSMUSP000000388382290271 Ensembl GO_REF:0000107 blood coagulation TAS 2290271 Reactome Reactome:R-HSA-109582 cell differentiation IBA PANTHER:PTN002521528 , RGD:621423 2290271 (PMID:21873635) GO_Central PMID:21873635 cellular response to DNA damage stimulus IDA 2290271 (PMID:10891478), (PMID:11517336) UniProtKB PMID:10891478 , PMID:11517336 cellular response to DNA damage stimulus IBA PANTHER:PTN000701011 , UniProtKB:P07948 2290271 (PMID:21873635) GO_Central PMID:21873635 cellular response to extracellular stimulus IEA UniProtKB:Q07014 , ensembl:ENSRNOP000000111302290271 Ensembl GO_REF:0000107 cellular response to heat IEA UniProtKB:Q07014 , ensembl:ENSRNOP000000111302290271 Ensembl GO_REF:0000107 cellular response to retinoic acid IMP 2290271 (PMID:17910947) BHF-UCL PMID:17910947 cytokine secretion IEA UniProtKB:Q07014 , ensembl:ENSRNOP000000111302290271 Ensembl GO_REF:0000107 dendritic cell differentiation ISS UniProtKB:P25911 2290271 UniProtKB GO_REF:0000024 dendritic cell differentiation IBA MGI:MGI:96892 , PANTHER:PTN000701011 2290271 (PMID:21873635) GO_Central PMID:21873635 ephrin receptor signaling pathway TAS 2290271 Reactome Reactome:R-HSA-2682334 erythrocyte differentiation ISS UniProtKB:P25911 2290271 UniProtKB GO_REF:0000024 Fc receptor mediated inhibitory signaling pathway ISS UniProtKB:P25911 2290271 UniProtKB GO_REF:0000024 Fc receptor mediated stimulatory signaling pathway ISS UniProtKB:P25911 2290271 UniProtKB GO_REF:0000024 Fc receptor mediated stimulatory signaling pathway IBA MGI:MGI:96892 , PANTHER:PTN000701011 2290271 (PMID:21873635) GO_Central PMID:21873635 Fc-epsilon receptor signaling pathway TAS 2290271 Reactome Reactome:R-HSA-2454202 Fc-gamma receptor signaling pathway involved in phagocytosis TAS 2290271 Reactome Reactome:R-HSA-2029480 growth hormone receptor signaling pathway via JAK-STAT TAS 2290271 Reactome Reactome:R-HSA-982772 histamine secretion by mast cell IEA UniProtKB:Q07014 , ensembl:ENSRNOP000000111302290271 Ensembl GO_REF:0000107 immune response-regulating cell surface receptor signaling pathway TAS 2290271 (PMID:15489917) UniProtKB PMID:15489917 immune response-regulating cell surface receptor signaling pathway ISS UniProtKB:P25911 2290271 UniProtKB GO_REF:0000024 innate immune response IEA UniProtKB-KW:KW-0399 2290271 UniProt GO_REF:0000037 intracellular signal transduction IEA UniProtKB:P25911 , ensembl:ENSMUSP000000388382290271 Ensembl GO_REF:0000107 leukocyte migration TAS 2290271 Reactome Reactome:R-HSA-202733 lipopolysaccharide-mediated signaling pathway ISS UniProtKB:P25911 2290271 UniProtKB GO_REF:0000024 negative regulation of B cell proliferation IBA MGI:MGI:96892 , PANTHER:PTN000701011 2290271 (PMID:21873635) GO_Central PMID:21873635 negative regulation of cell population proliferation IMP 2290271 (PMID:14726379) UniProtKB PMID:14726379 negative regulation of ERK1 and ERK2 cascade ISS UniProtKB:P25911 2290271 UniProtKB GO_REF:0000024 negative regulation of immune response TAS 2290271 (PMID:15489917) UniProtKB PMID:15489917 negative regulation of intracellular signal transduction ISS UniProtKB:P25911 2290271 UniProtKB GO_REF:0000024 negative regulation of MAP kinase activity ISS UniProtKB:P25911 2290271 UniProtKB GO_REF:0000024 negative regulation of mast cell proliferation ISS UniProtKB:P25911 2290271 UniProtKB GO_REF:0000024 negative regulation of mast cell proliferation IBA MGI:MGI:96892 , PANTHER:PTN000701011 2290271 (PMID:21873635) GO_Central PMID:21873635 negative regulation of myeloid leukocyte differentiation IEA UniProtKB:P25911 , ensembl:ENSMUSP000000388382290271 Ensembl GO_REF:0000107 negative regulation of protein phosphorylation ISS UniProtKB:P25911 2290271 UniProtKB GO_REF:0000024 negative regulation of toll-like receptor 2 signaling pathway ISS UniProtKB:P25911 2290271 UniProtKB GO_REF:0000024 negative regulation of toll-like receptor 4 signaling pathway ISS UniProtKB:P25911 2290271 UniProtKB GO_REF:0000024 neuron projection development IBA MGI:MGI:96892 , PANTHER:PTN000701011 2290271 (PMID:21873635) GO_Central PMID:21873635 oligodendrocyte development IEA UniProtKB:Q07014 , ensembl:ENSRNOP000000111302290271 Ensembl GO_REF:0000107 peptidyl-tyrosine autophosphorylation IBA PANTHER:PTN002521528 more ... 2290271 (PMID:21873635) GO_Central PMID:21873635 peptidyl-tyrosine phosphorylation IDA 2290271 (PMID:11782428), (PMID:7682714) UniProtKB PMID:11782428 , PMID:7682714 platelet activation TAS 2290271 Reactome Reactome:R-HSA-76002 platelet degranulation ISS UniProtKB:P25911 2290271 UniProtKB GO_REF:0000024 platelet degranulation IBA MGI:MGI:96892 , PANTHER:PTN000701011 2290271 (PMID:21873635) GO_Central PMID:21873635 positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process IMP 2290271 (PMID:24217950) ARUK-UCL PMID:24217950 positive regulation of cell migration IEA UniProtKB:P25911 , ensembl:ENSMUSP000000388382290271 Ensembl GO_REF:0000107 positive regulation of cell population proliferation ISS UniProtKB:P25911 2290271 UniProtKB GO_REF:0000024 positive regulation of cellular component movement IDA 2290271 (PMID:16467205) UniProtKB PMID:16467205 positive regulation of dendritic cell apoptotic process ISS UniProtKB:P25911 2290271 UniProtKB GO_REF:0000024 positive regulation of dendritic cell apoptotic process IBA MGI:MGI:96892 , PANTHER:PTN000701011 2290271 (PMID:21873635) GO_Central PMID:21873635 positive regulation of Fc receptor mediated stimulatory signaling pathway IEA UniProtKB:Q07014 , ensembl:ENSRNOP000000111302290271 Ensembl GO_REF:0000107 positive regulation of glial cell proliferation IEA UniProtKB:Q07014 , ensembl:ENSRNOP000000111302290271 Ensembl GO_REF:0000107 positive regulation of mast cell proliferation IMP 2290271 (PMID:11435302) UniProtKB PMID:11435302 positive regulation of neuron projection development IMP 2290271 (PMID:17910947) BHF-UCL PMID:17910947 positive regulation of oligodendrocyte progenitor proliferation IEA UniProtKB:Q07014 , ensembl:ENSRNOP000000111302290271 Ensembl GO_REF:0000107 positive regulation of phosphatidylinositol 3-kinase activity IEA UniProtKB:P25911 , ensembl:ENSMUSP000000388382290271 Ensembl GO_REF:0000107 positive regulation of phosphatidylinositol 3-kinase signaling TAS 2290271 Reactome Reactome:R-HSA-9027276 positive regulation of protein phosphorylation IGI UniProtKB:P20827 2290271 (PMID:24217950) ARUK-UCL PMID:24217950 positive regulation of Ras protein signal transduction TAS 2290271 Reactome Reactome:R-HSA-9027284 positive regulation of stress-activated protein kinase signaling cascade IDA 2290271 (PMID:10891478) UniProtKB PMID:10891478 positive regulation of tyrosine phosphorylation of STAT protein ISS UniProtKB:P25911 2290271 UniProtKB GO_REF:0000024 protein autophosphorylation IDA 2290271 (PMID:7682714) UniProtKB PMID:7682714 protein phosphorylation IDA 2290271 (PMID:11517336) UniProtKB PMID:11517336 regulation of B cell apoptotic process IBA MGI:MGI:96892 , PANTHER:PTN000701011 2290271 (PMID:21873635) GO_Central PMID:21873635 regulation of B cell receptor signaling pathway ISS UniProtKB:P25911 2290271 UniProtKB GO_REF:0000024 regulation of B cell receptor signaling pathway IBA MGI:MGI:96892 , PANTHER:PTN000701011 2290271 (PMID:21873635) GO_Central PMID:21873635 regulation of cell adhesion mediated by integrin IMP 2290271 (PMID:18802065) UniProtKB PMID:18802065 regulation of cell population proliferation IBA MGI:MGI:96892 more ... 2290271 (PMID:21873635) GO_Central PMID:21873635 regulation of cytokine production ISS UniProtKB:P25911 2290271 UniProtKB GO_REF:0000024 regulation of cytokine secretion IEA UniProtKB:P25911 , ensembl:ENSMUSP000000388382290271 Ensembl GO_REF:0000107 regulation of ERK1 and ERK2 cascade ISS UniProtKB:P25911 2290271 UniProtKB GO_REF:0000024 regulation of erythrocyte differentiation ISS UniProtKB:P25911 2290271 UniProtKB GO_REF:0000024 regulation of inflammatory response IEA UniProtKB:P25911 , ensembl:ENSMUSP000000388382290271 Ensembl GO_REF:0000107 regulation of mast cell activation ISS UniProtKB:P25911 2290271 UniProtKB GO_REF:0000024 regulation of mast cell degranulation ISS UniProtKB:P25911 2290271 UniProtKB GO_REF:0000024 regulation of mast cell degranulation IBA MGI:MGI:96892 , PANTHER:PTN000701011 2290271 (PMID:21873635) GO_Central PMID:21873635 regulation of monocyte chemotaxis IMP 2290271 (PMID:18802065) UniProtKB PMID:18802065 regulation of platelet aggregation ISS UniProtKB:P25911 2290271 UniProtKB GO_REF:0000024 regulation of platelet aggregation IBA MGI:MGI:96892 , PANTHER:PTN000701011 2290271 (PMID:21873635) GO_Central PMID:21873635 regulation of protein phosphorylation TAS 2290271 (PMID:15489917) UniProtKB PMID:15489917 regulation of release of sequestered calcium ion into cytosol IEA UniProtKB:P25911 , ensembl:ENSMUSP000000388382290271 Ensembl GO_REF:0000107 regulation of release of sequestered calcium ion into cytosol IEA UniProtKB:Q07014 , ensembl:ENSRNOP000000111302290271 Ensembl GO_REF:0000107 response to amino acid IEA UniProtKB:Q07014 , ensembl:ENSRNOP000000111302290271 Ensembl GO_REF:0000107 response to axon injury IEA UniProtKB:Q07014 , ensembl:ENSRNOP000000111302290271 Ensembl GO_REF:0000107 response to carbohydrate IEA UniProtKB:Q07014 , ensembl:ENSRNOP000000111302290271 Ensembl GO_REF:0000107 response to drug IEA UniProtKB:Q07014 , ensembl:ENSRNOP000000111302290271 Ensembl GO_REF:0000107 response to hormone ISS UniProtKB:P25911 2290271 UniProtKB GO_REF:0000024 response to insulin IEA UniProtKB:Q07014 , ensembl:ENSRNOP000000111302290271 Ensembl GO_REF:0000107 response to organic cyclic compound IEA UniProtKB:Q07014 , ensembl:ENSRNOP000000111302290271 Ensembl GO_REF:0000107 response to sterol depletion IEA UniProtKB:Q07014 , ensembl:ENSRNOP000000111302290271 Ensembl GO_REF:0000107 response to toxic substance IEA UniProtKB:Q07014 , ensembl:ENSRNOP000000111302290271 Ensembl GO_REF:0000107 signal transduction TAS 2290271 (PMID:7650013) PINC PMID:7650013 stimulatory C-type lectin receptor signaling pathway TAS 2290271 Reactome Reactome:R-HSA-5621481 T cell costimulation TAS 2290271 Reactome Reactome:R-HSA-388841, Reactome:R-HSA-389356 tolerance induction to self antigen TAS 2290271 (PMID:15489917) UniProtKB PMID:15489917 tolerance induction to self antigen IBA MGI:MGI:96892 , PANTHER:PTN000701011 2290271 (PMID:21873635) GO_Central PMID:21873635 tolerance induction to self antigen ISS UniProtKB:P25911 2290271 UniProtKB GO_REF:0000024 toll-like receptor 4 signaling pathway IEA UniProtKB:P25911 , ensembl:ENSMUSP000000388382290271 Ensembl GO_REF:0000107 transmembrane receptor protein tyrosine kinase signaling pathway IMP 2290271 (PMID:14726379) UniProtKB PMID:14726379 transmembrane receptor protein tyrosine kinase signaling pathway IBA MGI:MGI:105917 more ... 2290271 (PMID:21873635) GO_Central PMID:21873635 viral process IEA UniProtKB-KW:KW-0945 2290271 UniProtKB GO_REF:0000037
Cellular Component
adherens junction IEA UniProtKB:Q07014 , ensembl:ENSRNOP000000111302290271 Ensembl GO_REF:0000107 cytoplasm ISS UniProtKB:P25911 2290271 UniProtKB GO_REF:0000024 cytosol TAS 2290271 Reactome Reactome:R-HSA-114577 more ... extracellular exosome HDA 2290271 (PMID:23533145) UniProtKB PMID:23533145 extrinsic component of cytoplasmic side of plasma membrane IBA PANTHER:PTN002521528 more ... 2290271 (PMID:21873635) GO_Central PMID:21873635 glutamatergic synapse IEA UniProtKB:Q07014 , ensembl:ENSRNOP000000111302290271 Ensembl GO_REF:0000107 Golgi apparatus IDA 2290271 (PMID:15173188), (PMID:20605918) HPA GO_REF:0000052 more ... integrin alpha2-beta1 complex IEA UniProtKB:Q07014 , ensembl:ENSRNOP000000111302290271 Ensembl GO_REF:0000107 intracellular membrane-bounded organelle IDA 2290271 HPA GO_REF:0000052 mast cell granule IEA GO:0002553 2290271 GOC GO_REF:0000108 membrane raft IDA 2290271 (PMID:11313396) UniProtKB PMID:11313396 membrane raft ISS UniProtKB:P25911 2290271 ARUK-UCL GO_REF:0000024 mitochondrial crista IEA UniProtKB:Q07014 , ensembl:ENSRNOP000000111302290271 Ensembl GO_REF:0000107 mitochondrial intermembrane space IEA UniProtKB:Q07014 , ensembl:ENSRNOP000000111302290271 Ensembl GO_REF:0000107 nucleus IDA 2290271 (PMID:18817770) UniProtKB PMID:18817770 nucleus ISS UniProtKB:P25911 2290271 UniProtKB GO_REF:0000024 perinuclear region of cytoplasm IDA 2290271 (PMID:20605918) UniProtKB PMID:20605918 plasma membrane TAS 2290271 Reactome Reactome:R-HSA-2454208 more ... plasma membrane IDA 2290271 (PMID:15173188), (PMID:20605918) HPA GO_REF:0000052 more ... postsynaptic density IEA UniProtKB:Q07014 , ensembl:ENSRNOP000000111302290271 Ensembl GO_REF:0000107 postsynaptic specialization, intracellular component IEA UniProtKB:Q07014 , ensembl:ENSRNOP000000111302290271 Ensembl GO_REF:0000107
Molecular Function
ATP binding IEA UniProtKB-KW:KW-0067 2290271 UniProtKB GO_REF:0000037 enzyme binding IPI UniProtKB:O95573 2290271 (PMID:20605918) UniProtKB PMID:20605918 ephrin receptor binding IPI UniProtKB:P54764 2290271 (PMID:24217950) ARUK-UCL PMID:24217950 gamma-tubulin binding IEA UniProtKB:Q07014 , ensembl:ENSRNOP000000111302290271 Ensembl GO_REF:0000107 glycosphingolipid binding IEA UniProtKB:Q07014 , ensembl:ENSRNOP000000111302290271 Ensembl GO_REF:0000107 integrin binding IEA UniProtKB:Q07014 , ensembl:ENSRNOP000000111302290271 Ensembl GO_REF:0000107 ion channel binding IPI UniProtKB:Q9EPK8 2290271 (PMID:12538589) BHF-UCL PMID:12538589 ion channel binding IPI UniProtKB:Q9HBA0 2290271 (PMID:12538589) BHF-UCL PMID:12538589 kinase activity NAS 2290271 (PMID:24217950) ARUK-UCL PMID:24217950 non-membrane spanning protein tyrosine kinase activity IBA FB:FBgn0262733 more ... 2290271 (PMID:21873635) GO_Central PMID:21873635 non-membrane spanning protein tyrosine kinase activity TAS 2290271 Reactome Reactome:R-HSA-1168459 phosphoprotein binding IEA UniProtKB:Q07014 , ensembl:ENSRNOP000000111302290271 Ensembl GO_REF:0000107 phosphorylation-dependent protein binding IPI UniProtKB:Q8NDB2 2290271 (PMID:11782428) UniProtKB PMID:11782428 platelet-derived growth factor receptor binding IEA UniProtKB:Q07014 , ensembl:ENSRNOP000000111302290271 Ensembl GO_REF:0000107 protein binding IPI UniProtKB:P56945 2290271 (PMID:9020138) UniProtKB PMID:9020138 protein binding IPI UniProtKB:P14317 2290271 (PMID:23001182) BHF-UCL PMID:23001182 protein binding IPI UniProtKB:Q6UWF3 2290271 (PMID:21930792) IntAct PMID:21930792 protein binding IPI UniProtKB:Q9HCN6-1 2290271 (PMID:19940238) IntAct PMID:19940238 protein binding IPI UniProtKB:Q9NWQ8 2290271 (PMID:18070987), (PMID:23866081) IntAct PMID:18070987 , PMID:23866081 protein binding IPI UniProtKB:P12931 2290271 (PMID:18070987), (PMID:22581261) IntAct PMID:18070987 , PMID:22581261 protein binding IPI UniProtKB:P16671 2290271 (PMID:20037584) IntAct PMID:20037584 protein binding IPI UniProtKB:Q9WMX2 2290271 (PMID:14993658), (PMID:15784897) IntAct PMID:14993658 , PMID:15784897 protein binding IPI UniProtKB:O92972 2290271 (PMID:14993658), (PMID:15784897) IntAct PMID:14993658 , PMID:15784897 protein binding IPI UniProtKB:P25063 2290271 (PMID:22731636), (PMID:8753773) IntAct PMID:22731636 , PMID:8753773 protein binding IPI UniProtKB:Q9HCN6 2290271 (PMID:1715582), (PMID:19940238) IntAct PMID:1715582 , PMID:19940238 protein binding IPI UniProtKB:P00533 2290271 (PMID:16799092), (PMID:23764002), (PMID:23866081), (PMID:24658140) IntAct PMID:16799092 more ... protein binding IPI UniProtKB:Q08857 2290271 (PMID:20037584) IntAct PMID:20037584 protein binding IPI UniProtKB:P10721 2290271 (PMID:24728074) IntAct PMID:24728074 protein binding IPI UniProtKB:P08581 2290271 (PMID:24728074) IntAct PMID:24728074 protein binding IPI UniProtKB:Q13480 2290271 (PMID:24728074) IntAct PMID:24728074 protein binding IPI UniProtKB:P10275 2290271 (PMID:24728074) IntAct PMID:24728074 protein binding IPI UniProtKB:P63244 2290271 (PMID:23866081) IntAct PMID:23866081 protein binding IPI UniProtKB:P22575 2290271 (PMID:16155203) IntAct PMID:16155203 protein binding IPI UniProtKB:P33993 2290271 (PMID:23764002) IntAct PMID:23764002 protein binding IPI UniProtKB:P11049 2290271 (PMID:22624718) IntAct PMID:22624718 protein binding IPI UniProtKB:P27958 2290271 (PMID:14993658), (PMID:15784897) IntAct PMID:14993658 , PMID:15784897 protein binding IPI UniProtKB:O75807 2290271 (PMID:11517336) UniProtKB PMID:11517336 protein binding IPI UniProtKB:P27815 2290271 (PMID:11306681) UniProtKB PMID:11306681 protein binding IPI UniProtKB:Q6P5Z4 2290271 (PMID:9020138) UniProtKB PMID:9020138 protein binding IPI UniProtKB:O60711 2290271 (PMID:17640867) UniProtKB PMID:17640867 protein binding IPI UniProtKB:P03406 2290271 (PMID:7859737) UniProtKB PMID:7859737 protein binding IPI UniProtKB:P20273 2290271 (PMID:8647200) IntAct PMID:8647200 protein binding IPI UniProtKB:P05556 2290271 (PMID:20159608) IntAct PMID:20159608 protein binding IPI UniProtKB:P46527 2290271 (PMID:17254966) IntAct PMID:17254966 protein binding IPI UniProtKB:Q8R5G7 2290271 (PMID:15546919) IntAct PMID:15546919 protein tyrosine kinase activity EXP 2290271 (PMID:11358993), (PMID:11448999), (PMID:12670955), (PMID:12923167), (PMID:1381360), (PMID:18697750), (PMID:7526393), (PMID:9799234) Reactome PMID:11358993 more ... protein tyrosine kinase activity TAS 2290271 Reactome Reactome:R-HSA-1433506 more ... protein tyrosine kinase activity IDA 2290271 (PMID:10748115), (PMID:7682714) GO_Central PMID:10748115 , PMID:7682714 SH3 domain binding IEA UniProtKB:P25911 , ensembl:ENSMUSP000000388382290271 Ensembl GO_REF:0000107 signaling receptor binding IBA FB:FBgn0262733 more ... 2290271 (PMID:21873635) GO_Central PMID:21873635 ubiquitin protein ligase binding IEA UniProtKB:Q07014 , ensembl:ENSRNOP000000111302290271 Ensembl GO_REF:0000107