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Gene: Lyn (LYN proto-oncogene, Src family tyrosine kinase) Mus musculus
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Symbol: Lyn
Name: LYN proto-oncogene, Src family tyrosine kinase
Description: Exhibits SH3 domain binding activity and non-membrane spanning protein tyrosine kinase activity. Involved in several processes, including immune response-regulating signaling pathway; immune system development; and regulation of signal transduction. Localizes to several cellular components, including the membrane raft; nucleus; and plasma membrane. Used to study systemic lupus erythematosus. Is expressed in several structures, including alimentary system; genitourinary system; hemolymphoid system gland; liver and biliary system; and nervous system. Orthologous to human LYN (LYN proto-oncogene, Src family tyrosine kinase); PARTICIPATES IN eicosanoid signaling pathway; ephrin - ephrin receptor bidirectional signaling axis; erythropoietin signaling pathway; INTERACTS WITH 17alpha-ethynylestradiol; 2,3',4,4',5-Pentachlorobiphenyl; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: AA407514; Hck-2; p53Lyn; p56Lyn; tyrosine-protein kinase Lyn; V-yes-1 Yamaguchi sarcoma viral related oncogene homolog; Yamaguchi sarcoma viral (v-yes-1) oncogene homolog
Orthologs:
Homo sapiens (human) : LYN (LYN proto-oncogene, Src family tyrosine kinase)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Lyn (LYN proto-oncogene, Src family tyrosine kinase)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Lyn (LYN proto-oncogene, Src family tyrosine kinase)
Pan paniscus (bonobo/pygmy chimpanzee) : LYN (LYN proto-oncogene, Src family tyrosine kinase)
Canis lupus familiaris (dog) : LYN (LYN proto-oncogene, Src family tyrosine kinase)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Lyn (LYN proto-oncogene, Src family tyrosine kinase)
Sus scrofa (pig) : LYN (LYN proto-oncogene, Src family tyrosine kinase)
Chlorocebus sabaeus (green monkey) : LYN (LYN proto-oncogene, Src family tyrosine kinase)
Heterocephalus glaber (naked mole-rat) : Lyn (LYN proto-oncogene, Src family tyrosine kinase)
more info ...
Related Pseudogenes: Lyn-ps1  
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm38 Ensembl43,678,115 - 3,813,122 (+)Ensembl
GRCm3843,678,068 - 3,791,612 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv3743,605,268 - 3,718,759 (+)NCBIGRCm37mm9NCBIm37
MGSCv3643,605,272 - 3,718,759 (+)NCBImm8
MGSCv3643,205,785 - 3,233,451 (+)NCBImm8
Celera43,440,611 - 3,442,642 (-)NCBICelera
Celera43,623,471 - 3,748,466 (+)NCBICelera
Cytogenetic Map4 A1NCBI
cM Map42.05NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
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References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters

Additional Information

External Database Links
Nomenclature History
 
More on Lyn
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 732669
Created: 2004-01-12
Species: Mus musculus
Last Modified: 2019-11-27
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.